Results 51 to 60 of about 33,586 (298)

Basic Principle and Contact Analysis of Internal Meshing Gear Drive with Curve Configuration

Jixie chuandong, 2022
Based on gear transmission conjugate-curve theory research， taking the internal meshing gear transmission with curve element as the object， general meshing equation of spatial conjugate curves along the designated contact angle position is derived and ...
Dong Liang, Sheng Meng, Ming Li, Xiangyang Xu, Zeyin He   +4 more
doaj  

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Analysis of an Elasto-Hydrodynamic Seal by Using the Reynolds Equation

Applied Sciences, 2022
This paper reports numerical studies of an Elasto-Hydrodynamic (EHD) seal, which is being developed for supercritical CO2 (sCO2) turbomachinery applications. Current sCO2 turbomachinery suffers from high leakage rates, which is creating a major roadblock
Sevki Cesmeci, Karthik Reddy Lyathakula, Mohammad Fuad Hassan, Shuangbiao Liu, Hanping Xu, Jing Tang   +5 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Tykhonov well-posedness of fixed point problems in contact mechanics

Fixed Point Theory and Algorithms for Sciences and Engineering, 2022
We consider a fixed point problem S u = u $\mathcal {S}u=u$ where S : C ( R + ; X ) → C ( R + ; X ) ${\mathcal {S}:C(\mathbb{R}_{+};X)\to C(\mathbb{R}_{+};X)}$ is an almost history-dependent operator.
Mircea Sofonea
doaj   +1 more source

Operando Investigation on the Role of Densification and Chemo‐Mechanics on Solid‐State Cathodes

Advanced Energy Materials
All solid‐state batteries are desirable for a range of energy storage applications which require high energy density. Achieving a high energy density in a solid‐state battery requires the operation of an energy dense anode with a composite solid‐state ...
Min-Gi Jeong, K. Naik, Yanjie Zheng, Wonjoon Suk, B. Vishnugopi, Lin Lin, Dhanya Puthusseri, Andrew C Chuang, John S. Okasinski, Jeff Sakamoto, Partha P. Mukherjee, K. Hatzell   +11 more
semanticscholar   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

A finite element procedure for the analysis of thermo-mechanical solids in contact [PDF]

Computers & Structures, 2000
Abstract We present a finite element procedure for the analysis of fully coupled thermo-elasto-plastic response of solids including contact conditions. The continuum mechanics formulation for the solid and contact conditions is summarized and effective finite element techniques for solution are given.
Daniel Pantuso, Klaus-Jürgen Bathe, Pavel A. Bouzinov   +2 more
openaire   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Forward and inverse problems in the mechanics of soft filaments [PDF]

Royal Society Open Science, 2018
Soft slender structures are ubiquitous in natural and artificial systems, in active and passive settings and across scales, from polymers and flagella, to snakes and space tethers. In this paper, we demonstrate the use of a simple and practical numerical
M. Gazzola, L. H. Dudte, A. G. McCormick, L. Mahadevan   +3 more
doaj   +1 more source