Results 101 to 110 of about 4,940,955 (286)
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
CONTACT AND ROTATION ANALYSIS OF SINGLE ROLLER ENVELOPING FACE WORM DRIVE
Jixie qiangdu, 2021 Based on the meshing theory of single roller enveloping end face worm drive,the distribution of contact line and the length of contact line on the cylindrical surface of the drive pair,and the self-rotation angle of the roller,and the self-rotation angle
LIAO HongHui +3 more
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Jixie chuandong, 2014 The gear contact stress is very difficult to calculate and test owing to complexity of gear pairs contact condition by manufacturing error,assembly error,support conditions,deformation of loaded gear pairs,etc.The gear contact can be constituted of line ...
徐恺 +4 more
doaj
Contact Angle Profiles for Droplets on Omniphilic Surfaces in the Presence of Tangential Forces
Colloids and Interfaces, 2019 In real life, sessile droplets usually have a three-dimensional shape, making it difficult to understand their forced wetting behavior, both from an experimental and a theoretical perspective.
Margaritis Kostoglou +1 more
doaj +1 more source
Particle-Bubble Interactions: an Investigation of the Three-Phase Contact Line by Atomic Force Microscopy. [PDF]
Langmuir, 2023 Nicklas J, Ditscherlein L, Peuker UA.
europepmc +1 more source
FEBS Open Bio, EarlyView.A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li +6 more
wiley +1 more source
On the Moving Contact Line Singularity [PDF]
Doklady Physics, 2019 Given that contact line between liquid and solid phases can move regardless how negligibly small are the surface roughness, Navier slip, liquid volatility, impurities, deviations from the Newtonian behavior, and other system- dependent parameters, the problem is treated here from the pure hydrodynamical point of view only.
openaire +3 more sources
BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma
FEBS Open Bio, EarlyView.The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru +6 more
wiley +1 more source