Results 101 to 110 of about 1,427,336 (267)

The microbiome in human skin aging

open access: yesFEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana   +3 more
wiley   +1 more source

Modeling language contact with the Iterated Learning Model

open access: yesThe 2024 Conference on Artificial Life
to appear ...
Bullock, Seth, Houghton, Conor
openaire   +3 more sources

Calculation and Analysis of the Electrical Contact Resistance of the Strap Contacts Used in GIS Equipment Based on the Fractal Model

open access: yes工程科学与技术, 2023
Contact resistance of an electrical connection structure (ECR) is an important indicator to evaluate the reliability of the electrical contact system. The strap contact is an important electrical connection component in eco-friendly insulating gas GIS ...
Wei YANG   +4 more
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

open access: yesMolecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi   +11 more
wiley   +1 more source

Double pendulum contact problem

open access: yesApplied and Computational Mechanics, 2014
The work concerns contact problems focused on biomechanical systems modelled by a multibody approach. The example is modelling of impact between a body and an infrastructure. The paper firstly presents algorithm for minimum distance calculation.
Špička J., Hynčík L., Hajžman M.
doaj  

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