Results 101 to 110 of about 1,589,316 (316)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

Exploring the Relations Among Knowledge, Contact, and Transgender Prejudice [PDF]

open access: yes
Over the last few years there has been an increase in anti-trans rhetoric and violence towards transgender individuals, the consequences of which continue to adversely affect transgender people’s lives.
Cheso, Diana   +2 more
core   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

Changing children’s intergroup attitudes towards refugees: Testing different models of extended contact [PDF]

open access: yes, 2006
The present research evaluated an intervention, derived from the "extended contact hypothesis," which aimed to change children's intergroup attitudes toward refugees. The study (n=253) tested 3 models of extended contact among 5- to 11-year-old children:
Brown, Rupert   +7 more
core   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Administration of contact centres [PDF]

open access: yes, 2014
The objective of the audit was to assess how effectively and efficiently the ATO managed contact centres as part of its overall service delivery strategy. To form an opinion against the audit objective, the ANAO adopted the following high-level criteria:

core  

Peculiarities associated with testing polyetheretherketone (PEEK) in a model rolling contact [PDF]

open access: yes, 2015
Commonly used four-ball testing configuration when used to investigate rolling contact behavior of polyetheretherketone (PEEK) produced some unexpected peculiarities, namely direct contact between ceramic balls.
Stolarski, TA   +3 more
core   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Little Italy: an agent-based approach to the estimation of contact patterns- fitting predicted matrices to serological data [PDF]

open access: yes, 2010
Knowledge of social contact patterns still represents the most critical step for understanding the spread of directly transmitted infections. Data on social contact patterns are, however, expensive to obtain.
Billari Francesco C.   +39 more
core   +1 more source

Technological model of water contact iron removal

open access: yesJournal of Water and Land Development, 2018
Different types of filters are used to remove iron from underground water, one of them is foam polystyrene. Depending on the chemical water composition, tasks for water supply and other working conditions of iron-removing filters, it is necessary to ...
Martynov Serhii   +5 more
doaj   +1 more source

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