Results 111 to 120 of about 1,427,336 (267)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

BPS Skyrme Models and Contact Geometry

Reports on Mathematical Physics
14 ...
Slobodeanu, Radu, Speight, Martin
openaire   +2 more sources

Experimental validation of tire rolling contact pressure distribution by three-dimensional elastic ring model with pseudo-hysteresis characteristics

Nihon Kikai Gakkai ronbunshu
The contact characteristic of a tire is fundamental property that significantly influences handling stability, ride comfort, and environmental performance such as rolling resistance and wear. Although it has been experimentally confirmed that the rolling
Ryota NAKANISHI, Masami MATSUBARA, Haruyuki SUZUKI, Shozo KAWAMURA, Daiki TAJIRI   +4 more
doaj   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Effectiveness of enhancing contact model on reducing stigma of mental illness among family caregivers of persons with schizophrenia in rural China: A cluster randomized controlled trial. [PDF]

Lancet Reg Health West Pac, 2022
Ran MS, Wang YZ, Lu PY, Weng X, Weng X, Zhang TM, Deng SY, Li M, Luo W, Wong IY, Yang LH, Thornicroft G, Lu L.   +12 more
europepmc   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Verification Process Of Cylindrical Contact Force Models For Internal Contact Modeling

, 2013
{"references": ["R.S. Haines, Survey: 2-dimensional motion and impact at revolute joints,\nMechanism and Machine Theory, 15, pp. 361-370, 1980.", "J.A. Zukas, T. Nicholas, L.B. Greszczuk, D. R. Curran, Impact\nDynamics, John Wiley and Sons, New York, New York, 1982.", "R.R.
Cândida M. Pereira, Amílcar L. Ramalho, Jorge A. Ambrósio   +2 more
openaire   +2 more sources

Telehealth voice assessment by speech language pathologists during a global pandemic using principles of a primary contact model: an observational cohort study protocol. [PDF]

BMJ Open, 2022
Payten CL, Nguyen DD, Novakovic D, O'Neill J, Chacon AM, Weir KA, Madill CJ.   +6 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source