Results 101 to 110 of about 723,743 (264)

准双曲面齿轮齿面参数化方法研究

open access: yesJixie chuandong, 2005
A method to construct hypoid gear(HG) parameterized tooth surfaces with three types of parameters is presented.And their transformation relations have been demonstrated.The method is firstly utilized to refine the surface grid and to construct end curves.
王小林, 王延忠, 饶芳, 钟毅芳
doaj  

INFLUENCE OF ASSEMBLY ERRORS OF BEVEL GEAR PAIR ON THE MESH QUALITY [PDF]

open access: yesScientific Journal of Silesian University of Technology. Series Transport, 2014
The paper describes the influence of bevel gears assembly errors on the resulting contact pattern, which is an essential parameter for the mesh, both in the design and control of the transmission.
Jadwiga PISULA, Mieczysław PŁOCICA
doaj  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

open access: yesFEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill   +4 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

Effect of COVID-19 driven lockdown on social contact pattern in Puducherry, India: A longitudinal study.

open access: yesJ Postgrad Med, 2022
Kar SS   +4 more
europepmc   +1 more source

A yeast model of 5‐oxoproline accumulation reveals a general toleration to 5‐oxoproline

open access: yesFEBS Open Bio, EarlyView.
Using a yeast model, we show that even high accumulation of 5‐oxoproline causes only mild cellular stress and does not trigger oxidative stress. Instead, cells adapt by activating efflux pumps and diverse protective pathways, suggesting that previously proposed harmful effects of 5‐oxoproline may arise from indirect metabolic imbalances rather than the
Pratiksha Dubey   +4 more
wiley   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

open access: yesFEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin   +12 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Research on meshing characteristics of beveloid gear and involute cylindrical gear transmission with low crossed shaft angle

open access: yesJixie chuandong
ObjectiveIn view of the interference and block phenomenon caused by relatively wide displacement along the axial direction of crossed beveloid gears, a transmission type of beveloid gear and involute cylindrical gear transmission with low crossed shaft ...
NI Gaoxiang   +4 more
doaj  

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