Results 101 to 110 of about 4,303,287 (262)

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Analysis Method of Gear Profile Deformation,Transmission Error and Contact Pattern

Jixie chuandong, 2018
By using the LTCA analysis of involute gear,gear tooth deformation and stiffness curve with load is obtained. Then a study of the effect on meshing stiffness of drum shape modification across of gear width and lead misalignment is carried out by using of
Wang Ruixin, Yang Chao, Gong Yu, Liu Hongqi, Zhang Jingcai, Li Jinfeng   +5 more
doaj  

Predictive and prognostic biomarkers of Bacillus Calmette‐Guérin therapy failure in bladder cancer patients: A systematic review

Molecular Oncology, EarlyView.
High‐risk bladder cancer is typically treated with Bacillus Calmette‐Guérin (BCG), but 30–40% of patients relapse. No FDA‐ or CE‐approved biomarkers currently predict or prognosticate BCG failure. We systematically reviewed the literature and identified 72 eligible studies, revealing several promising biomarkers associated with BCG treatment response ...
Rui Ribeiro‐Pereira, Ana Teixeira‐Marques, Rui Freitas, João A Carvalho, Sara Monteiro‐Reis, Giorgio I. Russo, Rui Henrique, Carmen Jerónimo   +7 more
wiley   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source

Active Design of Contact Pattern and Experimental Verification of the Aero Spiral Bevel Gear

Jixie chuandong
In this study, an aero spiral bevel gear box is taken as the research object. An active design method for the bevel gear contact pattern is proposed. Firstly, the tooth surface design is carried out based on the macro parameters of spiral bevel gears and
Qian Lulu, Liu Hai'ou, Gao Jian, Lou Peng   +3 more
doaj  

Chemise and bloomers combination, 1920

, 1920
Pattern No. 4710: Combination chemise and bloomers with a curved gore set in at the crotch, elasticized leg openings, shoulder straps of ribbon, and a neckline trimmed with a ribbon bow. Bloomers can be made separately if desired. Additional information
Vogue Pattern Service
core  

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Embroidered shirtwaist, 1919

, 1919
Pattern No. 4778: Shirtwaist with a square neck and kimona-style sleeves that are "darted to the elbow at the lower edge and fastened with buttons." Embroidered material is set-in at the forearm and along the armhole of the shirtwaist.
Vogue Pattern Service
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Design of the Front Contact Metallization Patterns for Solar Cells Using Variable-Width Bezier Curves

Applied Sciences
The pattern of the front contact metallization critically influences solar cell efficiency. This study introduces a novel explicit geometry optimization approach for designing the front contact metallization patterns.
Kai Li, Yongjiang Liu, Peizheng Li
doaj   +1 more source