Results 91 to 100 of about 2,874,746 (299)

基于NURBS曲面的渐开线齿轮接触斑点解析及仿真

open access: yesJixie chuandong, 2014
According to the involute gear dynamic performance prediction,the whole involute gear tooth surface with modification is constructed based on NURBS by measurement of tooth surface to get the tooth surface data,and its accuracy is verified.Combining with ...
汪中厚, 马金妮, 康晓洁, 李刚
doaj  

AAA+ protein unfoldases—the Moirai of the proteome

open access: yesFEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Fabrication of Hydrophilic Surface on Rigid Gas Permeable Contact Lenses to Enhance the Wettability Using Ultraviolet Laser System

open access: yesMicromachines, 2019
The widely used rigid gas permeable (RGP) contact lenses provide higher oxygen permeability and tear exchange rate than do soft contact lenses. However, their wettability warrants improvement to enhance the wearing comfort.
Hsin-Yi Tsai   +5 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra   +6 more
wiley   +1 more source

Short-circuit current improvement in thin cells with a gridded back contact [PDF]

open access: yes
The use of gridded back contact on thin silicon solar cells 50 micrometers was investigated. An unexpected increase in short circuit current of almost 10 percent was experienced for 2 cm x 2 cm cells.
Giuliano, M., Wohlgemuth, J.
core   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

open access: yesMolecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann   +61 more
wiley   +1 more source

齿面研磨边界的确定与研齿性能试验

open access: yesJixie chuandong, 2007
Based on the tooth contact simulation and the analysis of transmission errors and contact ratio on the lapping process,the lapping boundary of the tooth surface is determined:±0.25~0.3 face width and ±0.1~0.25 tooth height in the middle of tooth surface ...
魏冰阳, 毛玺, 杨宏斌, 方宗德
doaj  

Rapid and mask-less laser-processing technique for the fabrication of microstructures in polydimethylsiloxane

open access: yes, 2014
We report a rapid laser-based method for structuring polydimethylsiloxane (PDMS) on the micron-scale. This mask-less method uses a digital multi-mirror device as a spatial light modulator to produce a given spatial intensity pattern to create arbitrarily
Butement, J.   +6 more
core   +1 more source

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