Results 61 to 70 of about 2,929,802 (304)

Control of Initiation, Rate, and Routing of Spontaneous Capillary-Driven Flow of Liquid Droplets through Microfluidic Channels on SlipChip [PDF]

, 2012
This Article describes the use of capillary pressure to initiate and control the rate of spontaneous liquid–liquid flow through microfluidic channels.
Ismagilov, Rustem F., Karymov, Mikhail A., Platt, Carol E., Pompano, Rebecca R.   +3 more
core   +3 more sources

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Moving contact lines in a pure-vapor atmosphere: a singularity-free description in the sole framework of classical physics [PDF]

, 2012
We here show that, even in the absence of "regularizing" microscopic effects (viz. slip at the wall or the disjoining pressure/precursor films), no singularities in fact arise for a moving contact line surrounded by the pure vapor of the liquid ...
Colinet, Pierre, Rednikov, Alexey
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Analysis and Improvement of Pantograph Carbon Strip Abnormal Wear on Luoyang Metro Line 1

Chengshi guidao jiaotong yanjiu
Objective During inspection, problems like the bad pantograph and catenary relation, pantograph-catenary arcing on the main line, burning points and serious wear on the pantograph carbon strip are detected since the trial operation of Luoyang Metro Line ...
WANG Liang, NIU Xiurong, LUO Min
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Benchmarking Signorini and exponential contact laws for an industrial train brake squeal application [PDF]

, 2012
Contact representation of structure interactions for finite element models is nowadays of great interest in the industry. Two contact modellig strategies exist in the literature, either based on a perfect contact with no interpenetration of structures at
BALMES, Etienne, CHIELLO, Olivier, LORANG, Xavier, VERMOT DES ROCHES, Guillaume   +3 more
core   +3 more sources

Nonlinear repulsive force between two solids with axial symmetry [PDF]

, 2011
We modify the formulation of Hertz contact theory between two elastic half-solids with axial symmetry and show that these modifications to Hertz’s original framework allow the development of force laws of the form F∝z^n, 10 to describe any aspect ratio ...
Daraio, Chiara, Sen, Surajit, Sun, Diankang   +2 more
core   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source