Results 71 to 80 of about 2,623,768 (284)

Modelling linered engine blocks [PDF]

, 1991
Factors that affect heat transfer in the linered aluminium engine block are examined to determine their importance. Conduction is found to be the dominant mode of heat transfer, and the interface is characterised as imperfect contact if there are no ...
Ha, J.
core  

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Modeling and finite element simulation of temperature field in rail abrasive belt grinding

Jin'gangshi yu moliao moju gongcheng
ObjectivesRail is an important component of rail transit, carrying train loads and guiding vehicle direction in service. Due to worn-outs and shocks during service, rails can cause various defects such as corrugation, spalling and squat, which seriously ...
Haipeng WANG, Jianyong LI, Chaoyue ZHAO, Yueming LIU   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Design of straight bevel gear for pitting resistance [PDF]

FME Transactions, 2018
Based on the Tredgold geometric approximation, a transparent contact stress capacity model for straight bevel gears is presented. A bevel load factor is defined which provides a kinetic link between the physical bevel gear and virtual spur gear.
Osakue Edward E., Lucky Anetor
doaj  

Stress concentration in the vicinity of a hole defect under conditions of Hertzian contact [PDF]

Two dimensional photoelastic stress analyses were conducted for epoxy resin models containing a hole defect under the conditions of Hertzian contact. Stress concentrations around the defect were determined as a function of several parameters.
Eguchi, M., Murayama, K., Yamamoto, T.
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Evaluation of contact stress distribution on the surface of tibial insert component: Finite element analysis [PDF]

Songklanakarin Journal of Science and Technology (SJST)
The purpose of this study was to evaluate and compare the contact stress distributions on the surface of the tibial insert between the posterior-stabilized (PS) and cruciate-retaining (CR) total knee arthroplasty (TKA).
Techin Seechaipat, Supakit Rooppakhun, Chotchuang Phombut   +2 more
doaj  

Moving Contact Line with Balanced Stress Singularities [PDF]

, 2009
A difficulty in the classical hydrodynamic analysis of moving contact-line problems, associated with the no-slip wall boundary condition resulting in an unbalanced divergence of the viscous stresses, is reexamined with a smoothed, finite-width interface model.
Hu, X. Y., Adams, N. A.
openaire   +2 more sources