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Autoimmune limbic encephalitis with anti-contactin-associated protein-like 2 antibody secondary to pembrolizumab therapy

Journal of Neuroimmunology, 2017
Immune checkpoint inhibitors such as Pembrolizumab are used to restore antitumour immune response. It is important to be vigilant of immune mediated adverse events related to such therapy. We report a case of autoimmune limbic encephalitis with Contactin-Associated Protein-like 2 (CASPR2) antibody secondary to Pembrolizumab therapy for metastatic ...
Pravin Hissaria   +2 more
exaly   +3 more sources

Contactin-associated protein-like 2, a protein of the neurexin family involved in several human diseases

European Journal of Neuroscience, 2018
AbstractContactin‐associated protein‐like 2 (CASPR2) is a cell adhesion protein of the neurexin family. Proteins of this family have been shown to play a role in the development of the nervous system, in synaptic functions, and in neurological diseases.
Jérôme Honnorat   +2 more
exaly   +3 more sources

Anti-contactin-associated protein-like 2 antibody autoimmune encephalitis with rapidly progressive parkinsonism: a case report and literature review

Acta Neurologica Belgica, 2022
Anti-contactin-associated protein-like 2 (CASPR2) antibody encephalitis is a rare autoimmune encephalitis (AE) that often presents with epilepsy, cognitive dysfunction, peripheral neuropathy, autonomic nerve damage, and ataxia. Parkinsonism is often observed in neurodegenerative diseases but progresses slowly, and rapidly progressive parkinsonism is ...
Xiaohong Qin   +6 more
openaire   +2 more sources

Contactin-associated protein-like 2 (CASPR2) autoantibody-related pancerebellar syndrome

Acta Neurologica Belgica, 2021
Hussein Algahtani   +3 more
openaire   +2 more sources

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