Results 61 to 70 of about 14,883 (287)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Optimization of Application Deployment Architecture in Container Orchestration

Journal of Applied Informatics and Computing
Container orchestration has become a widely adopted standard for application deployment among medium to large-scale organizations. Docker Swarm is one of the popular container orchestration tools due to its relatively simple configuration.
Mochamad Rizal Fachrudin, Ahmad Rofiqul Muslikh   +1 more
doaj   +1 more source

A Virtual Network PaaS for 3GPP 4G and Beyond Core Network Services

, 2016
Cloud computing and Network Function Virtualization (NFV) are emerging as key technologies to overcome the challenges facing 4G and beyond mobile systems.
Abu-Lebdeh, Mohammad, Glitho, Roch, Naboulsi, Diala, Tchouati, Constant Wette, Yangui, Sami   +4 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Optimized Encryption-Integrated Strategy for Containers Scheduling and Secure Migration in Multi-Cloud Data Centers

IEEE Access
Containers are recognized for their lightweight and virtualization efficiency, making them a vital element in modern application orchestration. In this context, the scheduler is crucial in strategically distributing containers across diverse computing ...
Mohammad A. Altahat, Tariq Daradkeh, Anjali Agarwal   +2 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

A Framework for Cognitive, Decentralized Container Orchestration

IEEE Access
This perspective paper introduces a novel framework for container orchestration called CODECO. The CODECO orchestration framework relies on a data-network-computing approach to define the best infrastructure that can support the operation of next ...
Rute C. Sofia, Josh Salomon, Simone Ferlin-Reiter, Luis Garces-Erice, Peter Urbanetz, Harald Mueller, Rizkallah Touma, Alejandro Espinosa, Luis M. Contreras, Vasileios Theodorou, Nikos Psaromanolakis, Lefteris Mamatas, Vassilis Tsaoussidis, Xiaoming Fu, Tingting Yuan, Alberto del Rio, David Jimenez, Andries Stam, Efterpi Paraskevoulakou, Panagiotis Karamolegkos, Vitor Vieira, Josep Martrat, Ignacio Mariscal Prusiel, Dorine Matzakou, John Soldatos, David Remon, Marco Jahn   +26 more
doaj   +1 more source

Service-oriented modeling for e-business applications components [PDF]

, 2001
The emerging trends for e-business engineering revolve around specialisation and cooperation. Successful companies focus on their core competences, and rely on a network of business partners for the support services required to compose a ...
Piccinelli, G., Salle, M., Zirpins, C.
core  

Comparison of Container Orchestration Engines

Integrated Journal for Research in Arts and Humanities
Container orchestration engines have become essential for managing containerized applications in modern cloud-native architectures. These tools automate the deployment, scaling, networking, and management of containers, enabling seamless application lifecycle management.
Samarth Shah, Ujjawal Jain
openaire   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gabor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source