Results 51 to 60 of about 1,073,941 (318)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, Volume 20, Issue 6, Page 1429-1452, June 2026.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Effects of application of rice husk biochar and limestone on cadmium accumulation in wheat under glasshouse and field conditions

Scientific Reports, 2022
Cadmium (Cd) has seriously threatened the safe production of food crops. Passivator amendments are commonly used to control the soil Cd availability. Yet, few studies are tested to explore the effect of the combination of various amendments.
Zehui Niu, Jiayan Ma, Xianzhi Fang, Zhaokun Xue, Zhengqian Ye   +4 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, Volume 20, Issue 6, Page 1453-1472, June 2026.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Aquifers Recharge and Contamination by Leaking Sewers - ARCLeakS

, 2023
The ARCLeakS (Aquifers Recharge and Contamination by Leaking Sewers) project aims to fill the existing theoretical and practical knowledge gap on the fate of contaminants originating from leaking sewers in the subsurface of urban environments.
Andrea D'Aniello
core  

Modeling of Groundwater Nitrate Contamination Due to Agricultural Activities—A Systematic Review

, 2022
Groundwater nitrate contamination is a significant concern in agricultural watersheds worldwide with it becoming a more pervasive problem in the last three decades.
Travis Wiederstein, Rintu Sen, Meenakshi Rawat, Ikenna Onyekwelu, Vaishali Sharda   +4 more
core   +1 more source

Advancement in utilization of magnetic catalysts for production of sustainable biofuels

Frontiers in Chemistry, 2023
In this study, we summarize recent advances in the synthesis of magnetic catalysts utilized for biodiesel production, particularly focusing on the physicochemical properties, activity, and reusability of magnetic mixed metal oxides, supported magnetic ...
Yutao Zhang, Yutao Zhang, Yutao Zhang, Weihua Li, Jialu Wang, Jiaxing Jin, Yixi Zhang, Jingsong Cheng, Qiuyun Zhang, Qiuyun Zhang, Qiuyun Zhang   +10 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, Volume 20, Issue 6, Page 1513-1534, June 2026.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Coupling of Multi-Hydrochemical and Statistical Methods for Identifying Apparent Background Levels of Major Components in Shallow Groundwater in Shanghai, China

Hydrology
The determination of groundwater background levels is a prerequisite for assessing and analyzing groundwater characteristics. Shanghai is among the most economically developed regions in China and is located in the estuary of the Yangtze River, where ...
Qingqing Li, Min Ji, Shiyang Zhang, Jie Yang, Hainan Lu   +4 more
doaj   +1 more source

Combined Effects of Microplastics and Biochar on the Removal of Polycyclic Aromatic Hydrocarbons and Phthalate Esters and Its Potential Microbial Ecological Mechanism

Frontiers in Microbiology, 2021
Microplastics (MPs) have been attracting wide attention. Biochar (BC) application could improve the soil quality in the contaminated soil. Currently, most studies focused on the effect of MPs or BC on the soil properties and microbial community, while ...
Xinwei Ren, Xinwei Ren, Xinwei Ren, Xinwei Ren, Jingchun Tang, Lan Wang, Hongwen Sun   +6 more
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, Volume 20, Issue 6, Page 1591-1611, June 2026.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source