Results 51 to 60 of about 1,280,182 (302)

Wheat straw- and maize straw-derived biochar effects on the soil cadmium fractions and bioaccumulation in the wheat–maize rotation system

open access: yesFrontiers in Environmental Science, 2022
Wheat–maize rotation is one of the most popular systems and successful intensification cropping systems in Northern China, while soils in some of this area are contaminated by cadmium (Cd). However, few studies have performed experiments on the reduction
Yu Dun   +8 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Conduits of contamination to contemporary food webs of the Norfolk Broads [PDF]

open access: yes, 2011
PhDDuring the 1960s-1980s antifouling applications containing the organotin tributyltin (TBT) were applied to craft on the Norfolk Broads, leaving a legacy of contaminants in sediments.
Laws, Jacob
core   +2 more sources

Geogenic contamination [PDF]

open access: yes, 2015
Contamination in drinking water, both chemical and microbiological, can originate from a range of sources, most of which are anthropogenic, such as agriculture, industry or human settlements (Fig. 2.1).
Johnston, Richard B. (author)   +2 more
core   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

open access: yesMolecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang   +9 more
wiley   +1 more source

Coupling of Multi-Hydrochemical and Statistical Methods for Identifying Apparent Background Levels of Major Components in Shallow Groundwater in Shanghai, China

open access: yesHydrology
The determination of groundwater background levels is a prerequisite for assessing and analyzing groundwater characteristics. Shanghai is among the most economically developed regions in China and is located in the estuary of the Yangtze River, where ...
Qingqing Li   +4 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

open access: yesMolecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou   +4 more
wiley   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani   +9 more
wiley   +1 more source

Anthropogenic Pb contribution in soils of Southeast China estimated by Pb isotopic ratios

open access: yesScientific Reports, 2020
Isotopic ratios were used to identify the source of Lead (Pb) contamination in rural soils from Southeast China. Enrichment of Pb in surface soils was detected from three sampling locations, with the 206Pb/207Pb ratio indicating recent anthropogenic ...
Jianwu Li   +4 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

open access: yesMolecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico   +5 more
wiley   +1 more source

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