Results 61 to 70 of about 1,239,341 (306)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Identifying human and animal faecal contamination in surface and drinking water : new concepts and approaches [PDF]

, 2011
Waterborne disease outbreaks caused by various pathogens have been reported from all over the world. They also play an important role in industrialized countries, despite good sanitation and high standards of hygiene.
Wicki, Melanie
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KWR-Water/Wastewater-contamination: Wastewater contamination v2.0

, 2023
Modeling the health impact of gross wastewater contamination events in drinking water ...
Marios S. Kyriakou, Sotirios Paraskevopoulos, Stelios G. Vrachimis   +2 more
core   +1 more source

The Impact of Magnesium on the Growth, Physiology and Quality of Tea (Camellia sinensis L.) Plants under Acid Stress

Agronomy
Magnesium plays a crucial role in plant physiological processes. However, the specific mechanisms underlying the response of tea plants to altered magnesium nutrition under acid stress remain unclear.
Xinhang Lv, Haimin Kong, Yubo Luo, Dubin Dong, Wenbin Liu, Dongtao Wu, Zhengqian Ye, Jiawei Ma, Dan Liu   +8 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Detection and Determination of Bacillus cereus in Cooked Rice and Some Types of Spices with Ribosomal 16SrRNA gene Selected from Iraqi Public Restaurants

International Journal of Bio-Resource and Stress Management, 2017
Spices can be considered as one of the sources of bacterial food pollution because of spices multiuse, in addition to the manufacturing processing and use, also they considered as one of food contamination reason due to the quantity of microorganisms ...
Ahmed Ibrahim Jessim, Saad Sabah Fakhry, Samarah Jafar Alwash   +2 more
doaj  

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Validating the cleanliness of contamination-critical products

, 2012
S.15-21Bei einer Vielzahl innovativer Produkte spielt die Kontrolle von Kontaminationen eine wesentliche Rolle. Trotz des Einsatzes angepasster Reinraumtechnik können dabei kritische Kontaminationen in der Massenproduktion nicht völlig ausgeschlossen ...
Kreck, Guido, Holzapfel, Yvonne
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Environmental contamination : a selection of papers presented at the 5th International Conference on Environmental Contamination, Morges, Switzerland, 29 September-1 October 1992 /

, 1993
This book deals with various aspects of environmental contamination. One of the fields considered in this work is atmospheric pollution. This has become a major problem of our time, and could soon develop into a scandal through the overestimation of the ...
Vernet, J.-P.(Jean-Pierre), International Conference on Environmental Contamination(5th :1992 :Morges, Switzerland)   +1 more
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