Results 61 to 70 of about 1,073,941 (318)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Anthropogenic Pb contribution in soils of Southeast China estimated by Pb isotopic ratios

Scientific Reports, 2020
Isotopic ratios were used to identify the source of Lead (Pb) contamination in rural soils from Southeast China. Enrichment of Pb in surface soils was detected from three sampling locations, with the 206Pb/207Pb ratio indicating recent anthropogenic ...
Jianwu Li, Guoshuang Hao, Xudong Wang, Li Ruan, Jinjie Zhou   +4 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Fecal contamination of drinking-water in low- and middle-income countries: a systematic review and meta-analysis

, 2014
Background: access to safe drinking-water is a fundamental requirement for good health and is also a human right. Global access to safe drinking-water is monitored by WHO and UNICEF using as an indicator “use of an improved source,” which does not ...
Bain, R, Ryan Cronk (560336), Jim Wright (560337), Bain, R., Jamie Bartram (359970), Bartram, J., Yang, H, Hong Yang, Bartram, J, Cronk, R, Yang, Hong, Bartram, Jamie, Tom Slaymaker, Slaymaker, Tom, Wright, J.A., Slaymaker, T., Ryan Cronk, Robert Bain (560335), Cronk, Ryan, Bain, Robert, Hong Yang (37298), Jim Wright, Tom Slaymaker (560338), Wright, Jim, Wright, J, Slaymaker, T, Cronk, R., Jamie Bartram, Robert Bain   +28 more
core   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

An Integrated Bayesian and Machine Learning Approach Application to Identification of Groundwater Contamination Source Parameters

, 2022
The identification of groundwater contamination source parameters is an important prerequisite for the control and risk assessment of groundwater contamination.
Yanxiang Zhang, Yongkai An, Xueman Yan
core   +1 more source

The Impact of Magnesium on the Growth, Physiology and Quality of Tea (Camellia sinensis L.) Plants under Acid Stress

Agronomy
Magnesium plays a crucial role in plant physiological processes. However, the specific mechanisms underlying the response of tea plants to altered magnesium nutrition under acid stress remain unclear.
Xinhang Lv, Haimin Kong, Yubo Luo, Dubin Dong, Wenbin Liu, Dongtao Wu, Zhengqian Ye, Jiawei Ma, Dan Liu   +8 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Detection and Determination of Bacillus cereus in Cooked Rice and Some Types of Spices with Ribosomal 16SrRNA gene Selected from Iraqi Public Restaurants

International Journal of Bio-Resource and Stress Management, 2017
Spices can be considered as one of the sources of bacterial food pollution because of spices multiuse, in addition to the manufacturing processing and use, also they considered as one of food contamination reason due to the quantity of microorganisms ...
Ahmed Ibrahim Jessim, Saad Sabah Fakhry, Samarah Jafar Alwash   +2 more
doaj  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source