Results 71 to 80 of about 1,280,182 (302)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Validating the cleanliness of contamination-critical products

, 2012
S.15-21Bei einer Vielzahl innovativer Produkte spielt die Kontrolle von Kontaminationen eine wesentliche Rolle. Trotz des Einsatzes angepasster Reinraumtechnik können dabei kritische Kontaminationen in der Massenproduktion nicht völlig ausgeschlossen ...
Kreck, Guido, Holzapfel, Yvonne
core   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Environmental Contamination and Industrial Real Estate Prices [PDF]

This article is the winner of the Industrial Real Estate manuscript prize (sponsored by Society of Industrial and Office REALTORS) presented at the American Real Estate Society Annual Meeting.
Thomas O. Jackson
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Remediation of Pb-, Zn-, Cu-, and Cd-Contaminated Soil in a Lead–Zinc Mining Area by Co-Cropping Ilex cornuta and Epipremnum aureum with Illite Application

Agriculture
Phytoremediation is considered an effective strategy for remediation of heavy-metal-contaminated soil in mining areas. However, single-species plants cannot reach the highest potential for uptake of heavy metals due to inhibition of their growth by high ...
Qi Li, Yanxin Tang, Dubin Dong, Xili Wang, Xuqiao Wu, Saima Gul, Yaqian Li, Xiaocui Xie, Dan Liu, Weijie Xu   +9 more
doaj   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Foreword to Digital cultures, innovation and startup. The contamination lab model. The contamination lab model

, 2020
Foreword to Digital cultures, innovation and startup. The contamination lab model.
Enrica Amaturo
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Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Genetic Contamination of Traditional Products [PDF]

Cross-pollination can be caused by birds, insects and wind. Genetically modified (GM) seeds are produced each year in a controlled environment to maintain their purity. However, pollen from the GM crop can be transferred to traditional crops. When the GM
E. Kwan Choi
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Detection of Biological Contamination

, 2022
S.575-580In various branches of technology or production contamination leads to loss of functionality of the produced items (i.e. chips) and so to loss of productivity and in the end to loss of money.
Trick, Iris, Kölblin, R., Grimme, R., Schüle, A.   +3 more
core