Results 91 to 100 of about 23,935,082 (334)

Open Content Alliance Update [PDF]

, 2008
As part of the Boston Library Consortium, in the fall of 2007 the University of New Hampshire Library began participating in the Open Content Alliance (OCA), a mass digitization project intended to make scanned library materials freely accessible to the ...
Exline, Eleta
core   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Restricted Boltzmann Machine-Based Approaches for Link Prediction in Dynamic Networks

IEEE Access, 2018
Link prediction in dynamic networks aims to predict edges according to historical linkage status. It is inherently difficult because of the linear/non-linear transformation of underlying structures.
Taisong Li, Bing Wang, Yasong Jiang, Yan Zhang, Yonghong Yan   +4 more
doaj   +1 more source

Improving Hybrid CTC/Attention Architecture with Time-Restricted Self-Attention CTC for End-to-End Speech Recognition

Applied Sciences, 2019
As demonstrated in hybrid connectionist temporal classification (CTC)/Attention architecture, joint training with a CTC objective is very effective to solve the misalignment problem existing in the attention-based end-to-end automatic speech recognition (
Long Wu, Ta Li, Li Wang, Yonghong Yan
doaj   +1 more source

Brane Content of Branes' States

, 2003
The problem of decomposition of unitary irreps of (super) tensorial (i.e. extended with tensorial charges) Poincar{\'e} algebra w.r.t. its different subalgebras is considered.
Abdel-Khalek, Baez, Bandos, Bandos, Bandos, Bars, Bars, Bars, Barut, de Azcarraga, Gauntlett, Gauntlett, Gunaydin, Gunaydin, Gunaydin, Kugo, Manvelyan, Manvelyan, Mkrtchyan, Mkrtchyan, Ruben Mkrtchyan, Townsend, Vasiliev, Wigner   +23 more
core   +2 more sources

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Intron‐oriented HTLV‐1 integration in an adult T‐cell leukemia/lymphoma cell line sustains expression of intact ift81 mRNA

FEBS Letters, EarlyView.
In the adult T‐cell leukemia/lymphoma (ATL) cell line ED, the human T‐cell leukemia virus type 1 (HTLV‐1) provirus was integrated into the intron of the ift81 gene in the antisense orientation. Despite this integration, both the intact ift81 and the viral oncogene hbz were simultaneously expressed, likely due to the functional insufficiency of viral ...
Mayuko Yagi, Yuka Hirosawa, Yusaku Sagisaka, Minami Hama, Satoshi Takeda, Jun A. Komano   +5 more
wiley   +1 more source

Does Phenomenology Ground Mental Content? [PDF]

, 2013
I develop several new arguments against claims about "cognitive phenomenology" and its alleged role in grounding thought content. My arguments concern "absent cognitive qualia cases", "altered cognitive qualia cases", and "disembodied cognitive qualia ...
Pautz, Adam
core  

Cyclic nucleotide signaling as a drug target in retinitis pigmentosa

FEBS Letters, EarlyView.
Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää, Ahmed B. Montaser, Henri Leinonen   +2 more
wiley   +1 more source

Applying deep matching networks to Chinese medical question answering: a study and a dataset

BMC Medical Informatics and Decision Making, 2019
Background Medical and clinical question answering (QA) is highly concerned by researchers recently. Though there are remarkable advances in this field, the development in Chinese medical domain is relatively backward.
Junqing He, Mingming Fu, Manshu Tu
doaj   +1 more source