Results 171 to 180 of about 1,341,632 (290)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Contextual information based anomaly detection for multi-scene aerial videos. [PDF]

Sci Rep
S G, Verma U, Pai MMM, Pai RM.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

iEnhancer-ELM: improve enhancer identification by extracting position-related multiscale contextual information based on enhancer language models. [PDF]

Bioinform Adv, 2023
Li J, Wu Z, Lin W, Luo J, Zhang J, Chen Q, Chen J.   +6 more
europepmc   +1 more source

NKCC1: A key regulator of glioblastoma progression

Molecular Oncology, EarlyView.
Glioblastoma (GBM) progression is driven by disrupted chloride cotransporter homeostasis. NKCC1 is highly expressed in stem‐like, astrocytic, and progenitor cells, correlating with earlier recurrence, while overall survival remains unaffected. NKCC1 serves as a prognostic marker and potential therapeutic target, linking chloride transporter imbalance ...
Anja Thomsen, Diana Freitag, Madlen Haase, Christian Senft, Falko Schwarz, Silke Keiner   +5 more
wiley   +1 more source

Utility of Multimodal Large Language Models in Analyzing Chest X-Rays with Incomplete Contextual Information. [PDF]

Healthc Inform Res
Kim C, Cho S, Yoon JH.
europepmc   +1 more source

Transmission Line Object Detection Method Based on Contextual Information Enhancement and Joint Heterogeneous Representation. [PDF]

Sensors (Basel), 2022
Zhao L, Liu C, Qu H.
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Nonlinear classification of neural manifolds with contextual information. [PDF]

Phys Rev E
Mignacco F, Chou CN, Chung S.
europepmc   +1 more source

An exploration of the impact of contextual information on the emotion recognition ability of autistic adults. [PDF]

Int J Psychol, 2022
Metcalfe D, McKenzie K, McCarty K, Pollet TV, Murray G, Murray G.   +5 more
europepmc   +1 more source