P-93. Contezolid in Patients with Spinal Infections [PDF]
Open Forum Infect DisAbstract Background Methicillin-resistant Staphylococcus aureus (MRSA) is a common cause of spinal infections (SI) requiring long-term use of antibiotic therapy. Linezolid (LZD) is effective in treating MRSA in different clinical scenarios, but its long-term use is limited due to risk of significant ...
Wei, Bo, Zhang, Xiucui, Wang, Jianrong
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Recent advances and challenges in antibacterial drug development [PDF]
, 2022 Beyer, Peter +2 more
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Investigation of Narrow Spectrum Targets in Antibacterial Drug Discovery [PDF]
, 2019 Background: Significant concerns are associated with the use of broad-spectrum antibacterial agents, including collateral eradication of beneficial bacteria from the human microbiome, the onset of antibacterial-associated infections, and continued ...
Jones, Jesse
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Antibacterial activity of synthetic peptide W5(Os-C) against Staphylococcus epidermidis ATCC 35984 [PDF]
Dissertation (MSc (Biochemistry))--University of Pretoria, 2024.Antimicriobial resistant Staphylococcus epidermidis infections are rapidly increasing. A promising research avenue is the use of antimicrobial peptides (AMPs).
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Pediatric Acute Myeloid Leukemia: Unraveling Complexities in Intensive Chemotherapy and the Emergence of Superbugs – A Case Study [PDF]
Sandip Patil, Xinye Li, Huirong Mai, Ying Wang, Xue Tang, Sixi Liu, Feiqiu Wen Department of Haematology and Oncology, Shenzhen Children’s Hospital, Shenzhen, Guangdong Province, People’s Republic of ChinaCorrespondence: Sixi Liu; Feiqiu Wen, Email ...
Li X +6 more
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Compassionate Use of Omadacycline in a Down Syndrome Pre-Schooler With Critically Ill Atypical Pneumonia Caused by Macrolide-Resistant Mycoplasma Pneumoniae [PDF]
Di Wu,1,* Feng-Jie Xie,2,* Ya-Jun Wang,3,* Xiao-Hui Jiang,1,* Guo-Li Zhang,3,* Hong Zhang,2 Yu-Cheng Zhu,4 Yan Zhang,4 Yu-Jia Tang,1 Yi-Lu Lin,1 Jia-Xi Xu,5 Jia-Ning Zhang,5 Bo-Wen Liu,5 Kai Kang,5 Yang Gao1 1Department of Critical ...
Gao Y +14 more
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, 2020 Contezolid (MRX-I), a new oxazolidinone, is an antibiotic in development for treating complicated skin and soft tissue infections caused by resistant Gram-positive bacteria.
Beining Guo +14 more
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Contezolid in tuberculosis therapy: a retrospective analysis of real-world practice in China
Abstract Background Linezolid (LZD), a pivotal agent in the treatment of tuberculosis (TB), is constrained by its adverse event (AE) profile. Contezolid (CZD), an innovative oxazolidinone derivative approved in China in 2021 for complicated skin and soft tissue infections, has been designed to refine the chemical structure of LZD ...
Senlin Zhan +8 more
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Targeting the Heart of Mycobacterium: Advances in Anti-Tubercular Agents Disrupting Cell Wall Biosynthesis [PDF]
Mycobacterium tuberculosis infections continue to pose a significant global health challenge, particularly due to the rise of multidrug-resistant strains, random mycobacterial mutations, and the complications associated with short-term antibiotic ...
Al Musaimi O, Diab A, Dickerson H
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Chemical approaches to understanding small-molecule accumulation in bacteria and poly(ADP-ribosyl)ation [PDF]
, 2019 The introduction of antibiotics revolutionized modern medicine. Surgical procedures became safer to perform, neonatal fatalities plummeted, and the risk of death from simple injuries was virtually eliminated.
Drown, Bryon Shane
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