Results 81 to 90 of about 5,130,669 (296)
Time after time – circadian clocks through the lens of oscillator theory
FEBS Letters, EarlyView.Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo +2 more
wiley +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
The Continued Fraction Structure in Physical Fractal Theory
Fractal and FractionalThe objective of this study is to reveal the intrinsic connection between fractal operators in physical fractal spaces and continued fractions. The specific contributions include: (1) reviewing fundamental concepts of continued fractions and physical ...
Ruiheng Jiang, Tianyi Zhou, Yajun Yin
doaj +1 more source
Molecular Oncology, EarlyView.This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert +13 more
wiley +1 more source
Diophantine approximations and almost periodic functions
Demonstratio Mathematica, 2017 In this paper we investigate the asymptotic behaviour of the classical continuous and unbounded almost periodic function in the Lebesgue measure.Using diophantine approximations we show that this function can be estimated by functions of polynomial type ...
Nawrocki Adam
doaj +1 more source
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
Dynamics of a continued fraction of Ramanujan with random coefficients
Abstract and Applied Analysis, 2005 We study a generalization of a continued fraction of Ramanujan with random, complex-valued coefficients. A study of the continued fraction is equivalent to an analysis of the convergence of certain stochastic difference equations and the stability of ...
Jonathan M. Borwein, D. Russell Luke
doaj +1 more source
Molecular Oncology, EarlyView.This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad +17 more
wiley +1 more source
On the metrical theory of a non-regular continued fraction expansion
Analele Stiintifice ale Universitatii Ovidius Constanta: Seria Matematica, 2015 We introduced a new continued fraction expansions in our previous paper. For these expansions, we show the Brodén-Borel-Lévy type formula. Furthermore, we compute the transition probability function from this and the symbolic dynamical system of the ...
Lascu Dan, Cîrlig George
doaj +1 more source