Results 71 to 80 of about 1,782,235 (304)

Medical Information Literacy and the Quality of the Medical Services. [PDF]

, 2007
Information Literacy is the library operation which makes the library user able to search, retrieve, evaluate, select and use the information resources.
Katsirikou, Anthi
core  

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

University, Samsung Partner on Groundbreaking Ed Tech Initiative [PDF]

, 2013
Starting with SAAHP and Continuing Studies, project aims to create collaborative learning environments, reduce technology costs for students and set new standards for “affordable excellence” in higher ...
Public Affairs, Roger Williams University
core   +1 more source

Understanding Quantitative Circadian Regulations Are Crucial Towards Advancing Chronotherapy

Cells, 2019
Circadian rhythms have a deep impact on most aspects of physiology. In most organisms, especially mammals, the biological rhythms are maintained by the indigenous circadian clockwork around geophysical time (~24-h).
Debajyoti Chowdhury, Chao Wang, Ai-Ping Lu, Hai-Long Zhu   +3 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The context, influences and challenges for undergraduate nurse clinical education: Continuing the dialogue [PDF]

, 2015
Introduction – Approaches to clinical education are highly diverse and becoming increasingly complex to sustain in complex milieu Objective – To identify the influences and challenges of providing nurse clinical education in the undergraduate setting ...
AIHW, Allan, Allan, Andrews, ANMAC, Annear, Arthur, Austria, Benner, Bernie Carter, Berragan, Bradshaw, Budgen, Buerhaus, Callaghan, Campbell, Chernomas, CIHI, Clinton, Courtney-Pratt, Cross, Daly, Debra Jackson, Dickson, Dobrowolska, Doiron, Donnelly, EU2005/36, European Commission, Fawcett, Hasson, Hayden, Holland, HWA, Jackson, Jackson, Jackson, Jan Forber, Jokelainen, Kardong-Edgren, Koch, Lauder, Mannix, Michelle DiGiacomo, Moscato, Moscato, Mulready-Shick, Myall, NHWT, Nielsen, Nishioka, NMC, NMC, O'Driscoll, Ostrogorsky, Patricia Davidson, Roxburgh, Ruth-Sahd, Salamonson, Sherman, Smith, Smith, Tanner, UKCC, Walker, Willis, Wolff   +66 more
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

The use of continuing adult education [PDF]

The objectives of the National Space Grant and Fellowship Program include the expansion of space-oriented educational programs beyond the traditional boundaries of university campuses to reach 'non-traditional' students whose personal and professional ...
Redd, Frank J.
core   +1 more source