Results 61 to 70 of about 7,611,916 (335)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Screening and treating problematic substance use among patients in psychiatry – obstacles and solutions

BMC Research Notes, 2023
Objective In Sweden, national guidelines recommend that all staff in the healthcare system systematically screen patients for alcohol use and illicit substance use. Where hazardous use is identified, it should be addressed as soon as possible, preferably
Elisabeth Petersén, Anne H Berman
doaj   +1 more source

Novine u standardu za obradu serijskih publikacija [PDF]

, 2005
In the Paper, is given new information about ISBD (CR) - the International Standard Bibliographic Description for Serials and Other Continuing Resources update of the previous standard ISBD (S) - International Standard Bibliographic Description ...
Vukotić, Bojana
core  

Natural resource potential of northern regions: methodological characteristics of comprehensive assessment [PDF]

, 2015
The economic assessment of renewable natural resources remains a relevant and as yet unresolved problem. Today, the economic assessment of natural resources is viewed as one of the priority tasks in the state strategy for environmental management.
Balashenko, V. V., Ignatyeva, M. N., Loginov, V. G.   +2 more
core   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Human Resources Policy. Case Study: Continuing Education Programs

Revista Transilvană de Ştiinţe Administrative, 2002
Life-long education programs are rather new in Romania, and there is much confusion about their structure, meaning, purposes and usefulness; although there is a clear necessity for these kinds of programs, they were implemented in our country only after ...
Cătălin BABA, Christian CHEREJI
doaj  

The burden of choice: decision regret in subspecialty selection among young and middle-aged doctors

BMC Medical Education
Background Subspecialty choice plays a pivotal role in physicians’ career satisfaction and professional trajectory. However, decision regret regarding subspecialty selection has been underexplored, despite its potential impact on well-being and retention.
Peixuan Guan, Maosha Fu, Feng Wu, Liru Hou, Weiyu Zhang   +4 more
doaj   +1 more source

The Teacher-Student Data Link Project: Three Lasting Accomplishments [PDF]

, 2014
In 2010, the Bill & Melinda Gates Foundation invited five states and three pilot districts in each state to participate in the Teacher-Student Data Link (TSDL) project.
Cassie Pickens Jewell, Kristin Hallgren, Sarah Wissel   +2 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source