Results 61 to 70 of about 5,071,485 (307)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The Role and Impact of Continuing Education on Rural Revitalization: A Case Study

, 2008
This article presents the findings of a study that explored the role and impact of continuing education on rural revitalization. A community development approach, academic expertise, and a university’s resources were used to assist the citizens of ...
Miller, Marilyn
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Determining continuing education needs of nurses in western Wisconsin [PDF]

, 2001
Plan BLife long learning is an essential component in professional growth. The Commission for a Nation of Lifelong Learners, a partnership of business, education, labor and government, recently released a report warning that America must continue to ...
Raddatz, Laurie L.
core  

A Survey on Health Information Services for People with Disabilities in Public Libraries and Librarians’ Competency Needs [PDF]

Journal of Library and Information Studies
To understand the development of health information services for people with disabilities in public libraries in Taiwan, this study utilized a questionnaire survey to gather information on the current status of health information services provided by ...
Chiao-Min Lin, Pei-Sin Zou
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

The fluorochrome-to-protein ratio is crucial for the flow cytometric detection of tissue factor on extracellular vesicles

Scientific Reports
Extracellular vesicles (EVs) have crucial roles in hemostasis and coagulation. They sustain coagulation by exposing phosphatidylserine and initiate clotting by surface expression of tissue factor (TF) under inflammatory conditions.
René Weiss, Marwa Mostageer, Tanja Eichhorn, Silke Huber, Dominik Egger, Andreas Spittler, Carla Tripisciano, Cornelia Kasper, Viktoria Weber   +8 more
doaj   +1 more source

Impact of microencapsulated phase change materials (PCMs) on the thermal and mechanical performance of cement mortar

Developments in the Built Environment
This study investigates the integration of Microencapsulated Phase Change Materials (MPCM) into cement mortar to enhance its thermal performance while assessing its mechanical and physical properties.
Iman Asadi, Guomin Ji, Gerald Steiner, Mohammad hajmohammadian baghban   +3 more
doaj   +1 more source

Static Digital Telepathology: A Model for Diagnostic and Educational Support to Pathologists in the Developing World

Analytical Cellular Pathology, 2012
Background: The practice of pathology in the developing world presents challenges in terms of limited resources, shortages of trained personnel, and lack of continuing education programs.
Aliyah R. Sohani, Moez A. Sohani
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source