Results 61 to 70 of about 217,645 (303)

Human Resources Policy. Case Study: Continuing Education Programs

Revista Transilvană de Ştiinţe Administrative, 2002
Life-long education programs are rather new in Romania, and there is much confusion about their structure, meaning, purposes and usefulness; although there is a clear necessity for these kinds of programs, they were implemented in our country only after ...
Cătălin BABA, Christian CHEREJI
doaj  

The burden of choice: decision regret in subspecialty selection among young and middle-aged doctors

BMC Medical Education
Background Subspecialty choice plays a pivotal role in physicians’ career satisfaction and professional trajectory. However, decision regret regarding subspecialty selection has been underexplored, despite its potential impact on well-being and retention.
Peixuan Guan, Maosha Fu, Feng Wu, Liru Hou, Weiyu Zhang   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

PRODUCTION OF THE PLAN FOR CONTINUING HEALTHEDUCATION: REPORT OF AN EXPERIENCE IN THE WESTERN REGION OF THE STATE OF SANTA CATARINA

Cogitare Enfermagem, 2015
Report of the experience of elaboration of the Plano de Ações Regionais de Educação Permanente em Saúde (regional action plan for continuing health education) in the western macro-region of the state of Santa Catarina, in 2014, by representatives of ...
Carine Vendruscolo, Denise Zocche, Altamir Trevisan Dutra   +2 more
doaj   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Community aspirations and hopes on groundwater governance: qualitative insights for climate change adaptation and resilience in semi–arid Dodoma, Tanzania

Frontiers in Water
IntroductionAspirations and hopes play a vital role in shaping ideas about water resource management. Due to increasing climate variability and a growing population, reliance on groundwater has risen in the Dodoma Region, threatening its sustainable use.
Devotha Baltazary Mosha, Johaiven Joel Kashaigili, Lina Patrice Samani, Japhet Joel Kashaigili, Joseph Rajabu Kangile   +4 more
doaj   +1 more source

A Survey on Health Information Services for People with Disabilities in Public Libraries and Librarians’ Competency Needs [PDF]

Journal of Library and Information Studies
To understand the development of health information services for people with disabilities in public libraries in Taiwan, this study utilized a questionnaire survey to gather information on the current status of health information services provided by ...
Chiao-Min Lin, Pei-Sin Zou
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source