Results 71 to 80 of about 5,072,790 (306)

Community aspirations and hopes on groundwater governance: qualitative insights for climate change adaptation and resilience in semi–arid Dodoma, Tanzania

Frontiers in Water
IntroductionAspirations and hopes play a vital role in shaping ideas about water resource management. Due to increasing climate variability and a growing population, reliance on groundwater has risen in the Dodoma Region, threatening its sustainable use.
Devotha Baltazary Mosha, Johaiven Joel Kashaigili, Lina Patrice Samani, Japhet Joel Kashaigili, Joseph Rajabu Kangile   +4 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Determining continuing education needs of nurses in western Wisconsin [PDF]

, 2001
Plan BLife long learning is an essential component in professional growth. The Commission for a Nation of Lifelong Learners, a partnership of business, education, labor and government, recently released a report warning that America must continue to ...
Raddatz, Laurie L.
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PRODUCTION OF THE PLAN FOR CONTINUING HEALTHEDUCATION: REPORT OF AN EXPERIENCE IN THE WESTERN REGION OF THE STATE OF SANTA CATARINA

Cogitare Enfermagem, 2015
Report of the experience of elaboration of the Plano de Ações Regionais de Educação Permanente em Saúde (regional action plan for continuing health education) in the western macro-region of the state of Santa Catarina, in 2014, by representatives of ...
Carine Vendruscolo, Denise Zocche, Altamir Trevisan Dutra   +2 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

The fluorochrome-to-protein ratio is crucial for the flow cytometric detection of tissue factor on extracellular vesicles

Scientific Reports
Extracellular vesicles (EVs) have crucial roles in hemostasis and coagulation. They sustain coagulation by exposing phosphatidylserine and initiate clotting by surface expression of tissue factor (TF) under inflammatory conditions.
René Weiss, Marwa Mostageer, Tanja Eichhorn, Silke Huber, Dominik Egger, Andreas Spittler, Carla Tripisciano, Cornelia Kasper, Viktoria Weber   +8 more
doaj   +1 more source

Impact of microencapsulated phase change materials (PCMs) on the thermal and mechanical performance of cement mortar

Developments in the Built Environment
This study investigates the integration of Microencapsulated Phase Change Materials (MPCM) into cement mortar to enhance its thermal performance while assessing its mechanical and physical properties.
Iman Asadi, Guomin Ji, Gerald Steiner, Mohammad hajmohammadian baghban   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

CCE connections

, 2011
Newsletter published 3 times per year by the Centre for Continuing Education at the University of Regina ...
Centre for Continuing Education
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