Results 101 to 110 of about 38,548 (295)

Phagosome-lysosome fusion is a calcium-independent event in macrophages. [PDF]

, 1996
Phagosome-lysosome membrane fusion is a highly regulated event that is essential for intracellular killing of microorganisms. Functionally, it represents a form of polarized regulated secretion, which is classically dependent on increases in ...
Ernst, JD, Gustavsson, M, Majeed, M, Sanan, DA, Stendahl, O, Zimmerli, S   +5 more
core   +2 more sources

Nanobody‐Conjugated Theranostic Prodrug Targeting αvβ3 Integrin Enables Precision Cancer Therapy With Real‐Time Imaging

Advanced Healthcare Materials, EarlyView.
The image shows a schematic form a nanobody‐conjugated theranostic prodrug (NBD) platform targeting tumor‐associated αvβ3 integrin. The NBD system integrates selective nanobody‐mediated tumor recognition, glutathione‐responsive disulfide cleavage for doxorubicin release, and aza‐BODIPY‐based near‐infrared fluorescence for real‐time imaging.
Sanu Karan, Hyunseung Lee, Rema Naskar, Mi Young Cho, Hye Sun Park, Eun Hee Han, Soumyadip Hore, Sun Hee Cho, Truc Ngoc Kim Lam, Taewoong Son, Tae Jung Park, Inkyu Hwang, Jonathan L. Sessler, Kwan Soo Hong   +13 more
wiley   +1 more source

Microflow Injection System for Efficient Cu(II) Detection across a Broad Range

Chemosensors
In this study, a modular, multi-step, photometric microflow injection analysis (micro-FIA) system for the automatic determination of Cu(II) in a bioreactor was developed.
David Ricart, Antonio David Dorado, Conxita Lao-Luque, Mireia Baeza   +3 more
doaj   +1 more source

Comorbidities in aging patients with sickle cell disease. [PDF]

, 2018
Sickle cell disease (SCD) in general and sickle cell anemia in particular is a highly complex disorder both at the molecular and clinical levels. Although the molecular lesion is a single-point mutation, the sickle gene is pleiotropic in nature causing ...
Ballas, Samir K.
core   +2 more sources

Bacteria‐Responsive Nanostructured Drug Delivery Systems for Targeted Antimicrobial Therapy

Advanced Materials, EarlyView.
Bacteria‐responsive nanocarriers are designed to release antimicrobials only in the presence of infection‐specific cues. This selective activation ensures drug release precisely at the site of infection, avoiding premature or indiscriminate release, and enhancing efficacy.
Guillermo Landa, Gracia Mendoza, Silvia Irusta, Manuel Arruebo   +3 more
wiley   +1 more source

Effect of different irrigation activation systems using continuous chelating irrigation protocol on the removal of smear layer in the apical third of root canals: An in vitro scanning electron microscope study

Endodontology
Aim: Continuous chelation is a novel irrigation regimen popular as a single solution for irrigation of the root canal system during root canal therapy, especially for the removal of the smear layer.
Nikitha D'Souza, Ashwini Santhosh, Anitha Kumari, Chethana S Murthy, Vikram Gowda, Sudhanva Mallandur   +5 more
doaj   +1 more source

TyG index and insulin resistance in beta-thalassemia [PDF]

, 2015
Insulin resistance (IR) underlies some glucose metabolism abnormalities in thalassemia major. Recently, triglyceride glucose index (TyG) has been proposed for evaluating insulin resistance as a simple, low cost, and accessible tool.
Fayaz, M., Hosseini, S.M., Jamshir, M., Mirbehbahani, N.   +3 more
core   +1 more source

Self‐Cooling Molecular Spin Qudits

Advanced Materials, EarlyView.
A material made of [GdEr] molecular dimers can encode a qudit and perform as a magnetic refrigerant. Microwave resonant pulses coherently manipulate its 16 spin states, while direct demagnetization measurements cool the material and a device down to temperatures below 1 K.
Elías Palacios, David Aguilà, David Gracia, Diamatoula Maniaki, Leoní A. Barrios, Alessandro Chiesa, Jesús I. Martínez, Valentin Novikov, Olivier Roubeau, Stefano Carretta, Marco Evangelisti, Guillem Aromí, Fernando Luis   +12 more
wiley   +1 more source

Coordination chemistry of amide-functionalised tetraazamacrocycles: structural, relaxometric and cytotoxicity studies [PDF]

, 2010
Three different tetraazamacrocyclic ligands containing four amide substituents that feature groups (namely allyl, styryl and propargyl groups) suitable for polymerisation have been synthesised.
Aime, Aime, Aime, Aime, Aime, Ali, Andrew J. P. White, Antoni, Beeta Balali-Mood, Behnam Azad, Bottrill, Bryson, Burdinski, Caravan, Cattaneo, Chapon, Cheng, Cilliers, De Leon-Rodriguez, De Leon-Rodriguez, Delgado, Faulkner, Fields, Gabriel, Guo, Hermann, Iten, Joachim H. G. Steinke, Jonathan Martinelli, Kaneshiro, Langereis, Major, Mani, Mark F. Lythgoe, Maumela, Montgomery, Moore, Muller, New, Oliver, Patrizia Ferretti, Pratesi, Rachael Panizzo, Ramon Vilar, Roosenburg, Schlesinger, Tan, Trokowski, Villaraza, Viola-Villegas, Viswanathan, Wu, Xu, Zhang, Zucchi   +54 more
core   +1 more source

Mesoporous Silica Nanoparticles in Biomedicine: Advances and Prospects

Advanced Materials, EarlyView.
Mesoporous silica nanoparticles offer unique properties like high surface area, tunable pores, and functionalization. They excel in drug delivery, tissue engineering, and stimuli‐responsive therapies, enabling targeted and controlled treatments. With roles in cancer therapy and diagnostics, their clinical translation requires addressing challenges in ...
Miguel Manzano, María Vallet‐Regí
wiley   +1 more source