Results 101 to 110 of about 3,776,942 (296)

Overcoming platinum resistance by the disulfiram metabolite CuET in novel preclinical models of human carcinomas

open access: yesMolecular Oncology, EarlyView.
Cisplatin‐resistant cancer cells survive DNA‐damaging platinum‐based treatment yet remain sensitive to CuET‐induced proteotoxic stress. The distinct mechanism of action allows CuET to overcome and eliminate cisplatin‐resistant tumour cells, unless highly expressed metallothioneins (MTs) interfere with CuET, thereby highlighting MT levels as candidate ...
Stefanos Arampatzis   +20 more
wiley   +1 more source

Einführung eines einheitlichen Vorgehens für Continuous Delivery mit .NET Anwendungen

open access: yes, 2015
Die Häufigkeit von Softwarereleases hat sich durch das Aufkommen der agilen Softwareentwicklung und durch die Ideen des Lean Thinking gesteigert. Aufgaben wie das Zusammenführen von Codeteilen und das Testen werden dadurch ebenfalls vermehrt eingesetzt ...
Holzer, Raoul
core  

Continuous Authentication for UAV Delivery Systems under Zero-Trust Security Framework

open access: yes, 2022
Continuous Authentication for UAV Delivery Systems under Zero-Trust Security ...
Xiao Liu (13082469)   +3 more
core  

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

open access: yesFEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay   +2 more
wiley   +1 more source

Old syndrome–new approach: Mauriac syndrome treated with continuous insulin delivery

open access: yesSAGE Open Medical Case Reports, 2018
Mauriac syndrome has rarely been reported in children and adolescents with a poorly controlled diabetes mellitus type 1. However, it still occurs despite the worldwide improvements of metabolic control. The risks have not been elucidated. We present a 13.
Mirjana Kocova, Liljana Milenkova
doaj   +1 more source

Multi-Robot Item Delivery and Foraging: Two Sides of a Coin

open access: yesRobotics, 2015
Multi-robot foraging has been widely studied in the literature, and the general assumption is that the robots are simple, i.e., with limited processing and carrying capacity.
Somchaya Liemhetcharat   +3 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

open access: yesFEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas   +6 more
wiley   +1 more source

Continuous Authentication for UAV Delivery Systems Under Zero-Trust Security Framework

open access: yes, 2023
Continuous Authentication for UAV Delivery Systems Under Zero-Trust Security ...
Shiping Chen (566714)   +3 more
core  

Protocol for quantifying miRNA trafficking across the endosomal membrane

open access: yesFEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh   +2 more
wiley   +1 more source

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