Results 61 to 70 of about 1,552,877 (295)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Comparing the Effects of Standard Maternity Care and Continuous Support by Doula Midwife and Female Relatives during Labor

Journal of Mazandaran University of Medical Sciences, 2020
Background and purpose: Pain in labor causes stress and reduces self-steem. Effective support is a key factor in reducing stress during delivery. The present study aimed to investigate and compare the effects of standard maternity care, continuous ...
Rozita Rezaei, Zahra Beheshti, Hamid Sharif Nia, Sussan Saatsaz   +3 more
doaj  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Anesthesia for cesarean section in a patient with respiratory failure -A case report- [PDF]

Korean Journal of Anesthesiology, 2013
We present successful epidural anesthesia and assisted mechanical ventilation in a parturient woman with respiratory failure. A 41-year-old woman at 35 weeks' of gestation was entering labor.
Hae Jin Lee, Jin Young Chon, Hyun-Jung Koh, Noh-Su Park, Ji-Young Lee   +4 more
doaj   +1 more source

Health Hazard Manual For Cutting Oils, Coolants, and Metalworking Fluids [PDF]

, 1991
[Excerpt] The metalworker can be exposed to cutting oils during application by two basic routes of entry: skin contact and inhalation. The higher risk jobs tend to be those with high cutting speeds, heavy oil flow, and continuous contact, which may ...
Brown, Nellie J
core   +1 more source

Beyond Continuous Delivery: An Empirical Investigation of Continuous Deployment Challenges [PDF]

, 2017
Context: A growing number of software organizations have been adopting Continuous DElivery (CDE) and Continuous Deployment (CD) practices. Researchers have started investing significant efforts in studying different aspects of CDE and CD.
Ali Babar, Muhammad, Shahin, Mojtaba, Zahedi, Mansooreh, Zhu, Liming   +3 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Continuous Epidural Hydromorphone Infusion for Post-Cesarean Delivery Analgesia in a Patient on Methadone Maintenance Therapy: A Case Report

Journal of Pain Research, 2020
Mellany A Stanislaus,1 Joseph L Reno,1 Robert H Small,1 Julie H Coffman,2 Mona Prasad,3 Avery M Meyer,4 Kristen M Carpenter,4 John C Coffman1 1Department of Anesthesiology, The Ohio State University Wexner Medical Center, Columbus, OH, USA; 2Department ...
Stanislaus MA, Reno JL, Small RH, Coffman JH, Prasad M, Meyer AM, Carpenter KM, Coffman JC   +7 more
doaj  

Adenovirus-mediated gene transfer to liver grafts: An improved method to maximize infectivity [PDF]

, 1998
Background. Adenoviral gene therapy in liver transplantation has many potential applications, but current vector delivery methods to grafts lack efficiency and require high titers. In this study, we attempted to improve gene delivery efficacy using three
Chia, SH, Fung, JJ, Geller, DA, Kibbe, MR, Murase, N, Starzl, TE, Watkins, SC   +6 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source