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What can we learn from Cyberpunk 2077’s disastrous launch? Cyberpunk 2077 was extensively advertised yet highly buggy release. Sony has pulled Cyberpunk 2077 from its PlayStation store following widespread complaints about glitches. The game lost over 75% of players on Steam.
openaire +1 more source
Scott & White Healthcare: Opening Up and Embracing Change to Improve Performance [PDF]
Offers a case study of a multispeciality system with the attributes of an ideal healthcare delivery system as defined by the Fund. Describes a culture of continuous improvement, collaboration and peer accountability, and a comprehensive approach to ...
Douglas McCarthy, Kimberly Mueller
core
Effect of Pulsed or Continuous Delivery of Salt on Sensory Perception Over Short Time Intervals [PDF]
Salt in the human diet is a major risk factor for hypertension and many countries have set targets to reduce salt consumption. Technological solutions are being sought to lower the salt content of processed foods without altering their taste.
A Okiyama +33 more
core +1 more source
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
A Delivery Robot Cloud Platform Based on Microservice
Delivery robots face the problem of storage and computational stress when performing immediate tasks, exceeding the limits of on-board computing power.
Zuozhong Yin +3 more
doaj +1 more source
Investigation of factors affecting the learning of final year advanced materials and manufacturing students [PDF]
An investigation was recently conducted into the delivery of an Advanced Materials and Manufacturing Processes module which was presented to a sub-group of the final year engineering students at Dublin City University (DCU).
Brabazon, Dermot +2 more
core
Implementation and performance analysis of a QoS-aware TFRC mechanism [PDF]
This paper deals with the improvement of transport protocol behaviour over the DiffServ Assured Forwarding (AF)class. The Assured Service (AS) provides a minimum throughput guarantee that classical congestion control mechanisms, like window-based in TCP ...
Dairaine, Laurent +5 more
core +3 more sources
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source

