Results 61 to 70 of about 360,304 (270)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Real-time observations of TRIP-induced ultrahigh strain hardening in a dual-phase CrMnFeCoNi high-entropy alloy. [PDF]

, 2020
Strategies involving metastable phases have been the basis of the design of numerous alloys, yet research on metastable high-entropy alloys is still in its infancy.
Chen, Sijing, Gludovatz, Bernd, Kim, Sang Jun, Oh, Hyun Seok, Park, Eun Soo, Ritchie, Robert O, Yu, Qian, Zhang, Ze   +7 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Step Towards Real-Time Release Testing of Pharmaceutical Tablets: Utilization of CIELAB Color Space

Pharmaceutics
Background: The pharmaceutical industry is shifting from end-product testing towards real-time release testing. This approach is based on the continuous collection of process data and product information, which is finally utilized for the release ...
René Brands, Trieu Nam Le, Jens Bartsch, Markus Thommes   +3 more
doaj   +1 more source

Spondylitis transmitted from infected aortic grafts: a review [PDF]

Journal of Bone and Joint Infection, 2017
Graft infection following aortic aneurysms repair is an uncommon but devastating complication; its incidence ranges from <1% to 6% (mean 4%), with an associated perioperative and overall mortality of 12% and 17.5-20%, respectively.
P. D. Megaloikonomos, T. Antoniadou, L. Dimopoulos, M. Liontos, V. Igoumenou, G. N. Panagopoulos, E. Giannitsioti, A. Lazaris, A. F. Mavrogenis   +8 more
doaj   +1 more source

Empirical Comparison of Chirp and Multitones on Experimental UWB Software Defined Radar Prototype [PDF]

, 2012
This paper proposes and tests an approach for an unbiased study of radar waveforms' performances. Using the ultrawide band software defined radar prototype, the performances of Chirp and Multitones are compared in range profile and detection range.
Denoulet, J., Garda, P., Le Kernec, J., Romain, O.   +3 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Optimising Spatial and Tonal Data for PDE-based Inpainting

, 2015
Some recent methods for lossy signal and image compression store only a few selected pixels and fill in the missing structures by inpainting with a partial differential equation (PDE).
Doerr, Benjamin, Hoeltgen, Laurent, Hoffmann, Sebastian, Johannsen, Daniel, Mainberger, Markus, Neumann, Frank, Setzer, Simon, Tang, Ching Hoo, Weickert, Joachim   +8 more
core   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Investigation of the Optimal Pressure for Skin Grafting Using Negative Pressure Wound Therapy

Plastic and Reconstructive Surgery, Global Open
Background:. Recent studies suggest that negative pressure wound therapy (NPWT) is more effective than tie-over bolsters for skin graft fixation, improving graft take rates and reducing operation times. However, the relationship between negative pressure
Aoi Hashimoto, MD, Mariko Ota, MD, Chizuru Umeda, MD, PhD, Koichi Ueda, MD, PhD, Takashi Nuri, MD, PhD   +4 more
doaj   +1 more source