Results 1 to 10 of about 223,531 (304)

Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures. [PDF]

J Control Release, 2023
Messenger RNA (mRNA) lipid nanoparticles (LNPs) have emerged at the forefront during the COVID-19 vaccination campaign. Despite their tremendous success, mRNA vaccines currently require storage at deep freeze temperatures which complicates their storage and distribution, and ultimately leads to lower accessibility to low- and middle-income countries ...
Meulewaeter S, Nuytten G, Cheng MHY, De Smedt SC, Cullis PR, De Beer T, Lentacker I, Verbeke R.   +7 more
europepmc   +7 more sources

Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying [PDF]

Pharmaceutics, 2021
During the spin freezing step of a recently developed continuous spin freeze-drying technology, glass vials are rapidly spun along their longitudinal axis.
Gust Nuytten, Susan Ríos Revatta, Pieter-Jan Van Bockstal, Ashish Kumar, Joris Lammens, Laurens Leys, Brecht Vanbillemont, Jos Corver, Chris Vervaet, Thomas De Beer   +9 more
doaj   +6 more sources

A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying [PDF]

Pharmaceutics, 2021
The pharmaceutical industry is progressing toward the development of more continuous manufacturing techniques. At the same time, the industry is striving toward more process understanding and improved process control, which requires the implementation of
Laurens Leys, Gust Nuytten, Joris Lammens, Pieter-Jan Van Bockstal, Jos Corver, Chris Vervaet, Thomas De Beer   +6 more
doaj   +7 more sources

Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses [PDF]

International Journal of Pharmaceutics, 2017
In the pharmaceutical industry, traditional freeze-drying of unit doses is a batch-wise process associated with many disadvantages. To overcome these disadvantages and to guarantee a uniform product quality and high process efficiency, a continuous ...
Corver, Jos, De Beer, Thomas, De Meyer, Laurens, Lammens, Joris, Mortier, Séverine, Nopens, Ingmar, Van Bockstal, Pieter-Jan, Vanbillemont, Brecht, Vervaet, Chris   +8 more
core   +7 more sources

A primary drying model-based comparison of conventional batch freeze-drying to continuous spin-freeze-drying for unit doses [PDF]

European Journal of Pharmaceutics and Biopharmaceutics, 2020
An innovative continuous spin-freeze-drying technology for unit doses was recently developed. For this technology, a mechanistic primary drying model was developed allowing the calculation of the optimal dynamic drying trajectory for spin-frozen formulations.
L, Leys, B, Vanbillemont, P J, Van Bockstal, J, Lammens, G, Nuytten, J, Corver, C, Vervaet, T, De Beer   +7 more
semanticscholar   +5 more sources

Spray Freeze-Drying as a Solution to Continuous Manufacturing of Pharmaceutical Products in Bulk [PDF]

Processes, 2020
Pharmaceutical manufacturing is evolving from traditional batch processes to continuous ones. The new global competition focused on throughput and quality of drug products is certainly the driving force behind this transition which, thus, represents the new challenge of pharmaceutical manufacturing and hence of lyophilization as a downstream operation.
Adali M. B., Barresi A. A., Boccardo G., Pisano R.   +3 more
semanticscholar   +4 more sources

Mechanistic modelling of infrared mediated energy transfer during the primary drying step of a continuous freeze-drying process [PDF]

European Journal of Pharmaceutics and Biopharmaceutics, 2017
Conventional pharmaceutical freeze-drying is an inefficient and expensive batch-wise process, associated with several disadvantages leading to an uncontrolled end product variability. The proposed continuous alternative, based on spinning the vials during freezing and on optimal energy supply during drying, strongly increases process efficiency and ...
Van Bockstal, Pieter-Jan, Mortier, Séverine, De Meyer, Laurens, Corver, Jos, Vervaet, Chris, Nopens, Ingmar, De Beer, Thomas   +6 more
semanticscholar   +6 more sources

Noncontact Infrared-Mediated Heat Transfer During Continuous Freeze-Drying of Unit Doses [PDF]

Journal of Pharmaceutical Sciences, 2017
Recently, an innovative continuous freeze-drying concept for unit doses was proposed, based on spinning the vials during freezing. An efficient heat transfer during drying is essential to continuously process these spin frozen vials. Therefore, the applicability of noncontact infrared (IR) radiation was examined.
Van Bockstal, Pieter-Jan, De Meyer, Laurens, Corver, Jos, Vervaet, Chris, De Beer, Thomas   +4 more
openaire   +4 more sources

Production of components for special-purpose products at continuous freeze drying of plants [PDF]

IOP Conference Series: Earth and Environmental Science, 2019
Abstract Experimental studies on freeze-drying of juices and fermented milk drinks at continuous plants were carried out. High-quality components comparable with raw materials for the production of special-purpose products are obtained.
N Kasatkina, V Kasatkin, A Zorin
openaire   +2 more sources

Thermal Imaging as a Noncontact Inline Process Analytical Tool for Product Temperature Monitoring during Continuous Freeze-Drying of Unit Doses [PDF]

Analytical Chemistry, 2018
Freeze-drying is a well-established technique to improve the stability of biopharmaceuticals which are unstable in aqueous solution. To obtain an elegant dried product appearance, the temperature at the moving sublimation interface Ti should be kept below the critical product temperature Ti,crit during primary drying.
Pieter-Jan Van Bockstal, Jos Corver, Laurens De Meyer, Chris Vervaet, Thomas De Beer   +4 more
openaire   +3 more sources