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Development and Application of a Mechanistic Cooling and Freezing Model of the Spin Freezing Step within the Framework of Continuous Freeze-Drying [PDF]

Pharmaceutics, 2021
During the spin freezing step of a recently developed continuous spin freeze-drying technology, glass vials are rapidly spun along their longitudinal axis.
Gust Nuytten, Susan Ríos Revatta, Pieter-Jan Van Bockstal, Ashish Kumar, Joris Lammens, Laurens Leys, Brecht Vanbillemont, Jos Corver, Chris Vervaet, Thomas De Beer   +9 more
doaj   +5 more sources

A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying [PDF]

Pharmaceutics, 2021
The pharmaceutical industry is progressing toward the development of more continuous manufacturing techniques. At the same time, the industry is striving toward more process understanding and improved process control, which requires the implementation of
Laurens Leys, Gust Nuytten, Joris Lammens, Pieter-Jan Van Bockstal, Jos Corver, Chris Vervaet, Thomas De Beer   +6 more
doaj   +4 more sources

Continuous freeze-drying of messenger RNA lipid nanoparticles enables storage at higher temperatures. [PDF]

J Control Release, 2023
Messenger RNA (mRNA) lipid nanoparticles (LNPs) have emerged at the forefront during the COVID-19 vaccination campaign. Despite their tremendous success, mRNA vaccines currently require storage at deep freeze temperatures which complicates their storage and distribution, and ultimately leads to lower accessibility to low- and middle-income countries ...
Meulewaeter S, Nuytten G, Cheng MHY, De Smedt SC, Cullis PR, De Beer T, Lentacker I, Verbeke R.   +7 more
europepmc   +4 more sources

Modelling the primary drying step for the determination of the optimal dynamic heating pad temperature in a continuous pharmaceutical freeze-drying process for unit doses [PDF]

International Journal of Pharmaceutics, 2017
In the pharmaceutical industry, traditional freeze-drying of unit doses is a batch-wise process associated with many disadvantages. To overcome these disadvantages and to guarantee a uniform product quality and high process efficiency, a continuous freeze-drying process is developed and evaluated.
De Meyer, Laurens, Lammens, Joris, Mortier, Séverine, Vanbillemont, Brecht, Van Bockstal, Pieter-Jan, Corver, Jos, Nopens, Ingmar, Vervaet, Chris, De Beer, Thomas   +8 more
openaire   +5 more sources

Mechanistic Modeling of Continuous Lyophilization for Biopharmaceutical Manufacturing [PDF]

Advanced Science
Lyophilization (aka freeze drying) is a typical process in (bio)pharmaceutical manufacturing used for improving the stability of various drug products, including its recent applications to mRNA vaccines.
Prakitr Srisuma, Gang Chen, Richard D. Braatz   +2 more
doaj   +2 more sources

Current Status of Grain Drying Technology and Equipment Development: A Review [PDF]

Foods
Grain drying technology is a core process for ensuring food quality, extending storage life, and improving processing adaptability. With the continuous growth of global food demand and the increasing requirements for food quality and energy efficiency ...
Pengpeng Yu, Wenhui Zhu, Chaoping Shen, Yu Qiao, Wenya Zhang, Yansheng Zhu, Jun Gong, Jianrong Cai   +7 more
doaj   +2 more sources

Botanical Nanofiber Wound Dressing Loaded with Psidium guajava Leaf Extract: Preparation, Characterization, and In Vivo Evaluation [PDF]

Pharmaceutics
Background/Objectives: This study aimed to develop botanical nanofibers loaded with Psidium guajava leaf extract to heal wounds effectively. Methods: A 23 factorial design was conducted to study the impact of freeze-drying parameters—freezing time ...
Menna M. Abdellatif, Hesham A. Eliwa, Mohamed Aly Abd El Aziz El Degwy, Samah Shabana, Rafik M. Nassif, Hamada Sadki Mohamed, Rehab Abdelmonem   +6 more
doaj   +2 more sources

A primary drying model-based comparison of conventional batch freeze-drying to continuous spin-freeze-drying for unit doses [PDF]

European Journal of Pharmaceutics and Biopharmaceutics, 2020
An innovative continuous spin-freeze-drying technology for unit doses was recently developed. For this technology, a mechanistic primary drying model was developed allowing the calculation of the optimal dynamic drying trajectory for spin-frozen formulations.
L, Leys, B, Vanbillemont, P J, Van Bockstal, J, Lammens, G, Nuytten, J, Corver, C, Vervaet, T, De Beer   +7 more
openaire   +2 more sources

Spin Freezing and Its Impact on Pore Size, Tortuosity and Solid State

Pharmaceutics, 2021
Spin freeze-drying, as a part of a continuous freeze-drying technology, is associated with a much higher drying rate and a higher level of process control in comparison with batch freeze-drying.
Joris Lammens, Niloofar Moazami Goudarzi, Laurens Leys, Gust Nuytten, Pieter-Jan Van Bockstal, Chris Vervaet, Matthieu N. Boone, Thomas De Beer   +7 more
doaj   +1 more source

Drying efficiency and quality preservation of blackberries (Rubus spp. variety Tupy) in the near and mid-infrared-assisted freeze-drying

Food Chemistry Advances, 2023
The influence of infrared radiation-assisted freeze-drying (IRFD) on the process efficiency and quality of blackberries (Rubus spp. variety Tupy) was evaluated.
Natália Leite Oliveira, Ana Cláudia Silveira Alexandre, Sérgio Henrique Silva, Jayne de Abreu Figueiredo, Adrise Aparecida Rodrigues, Jaime Vilela de Resende   +5 more
doaj   +1 more source