Results 11 to 20 of about 223,531 (304)

Evaluation of spin freezing versus conventional freezing as part of a continuous pharmaceutical freeze-drying concept for unit doses [PDF]

International Journal of Pharmaceutics, 2015
Spin-freezing as alternative freezing approach was evaluated as part of an innovative continuous pharmaceutical freeze-drying concept for unit doses. The aim of this paper was to compare the sublimation rate of spin-frozen vials versus traditionally frozen vials in a batch freeze-dryer, and its impact on total drying time.
De Meyer, Laurens, Van Bockstal, Pieter-Jan, Corver, Jos, Vervaet, Chris, Remon, Jean Paul, De Beer, Thomas   +5 more
semanticscholar   +5 more sources

Continuous alternative to freeze drying: Manufacturing of cyclodextrin-based reconstitution powder from aqueous solution using scaled-up electrospinning

Journal of Controlled Release, 2019
The aims of this study were to evaluate electrospinning as a continuous alternative to freeze drying in the production of a reconstitution injection dosage form, and to prove that aqueous electrospinning can be realized with a high production rate at room temperature.
Panna Vass, Balázs Démuth, Attila Farkas, Edit Hirsch, Edina Szabó, Brigitta Nagy, Sune K. Andersen, Tamás Vigh, Geert Verreck, István Csontos, György Marosi, Zsombor K. Nagy   +11 more
semanticscholar   +5 more sources

Recent trends in pharmaceutical freeze-drying and control strategies observed in human drug applications and manufacturing inspections [PDF]

AAPS Open
Freeze-drying has been a workhorse for the pharmaceutical industry to enable long-term storage and long-distance transport of drug products that are unstable in liquid or frozen form.
Steve Y. Rhieu, Maxwell Korang-Yeboah, David D. Anderson, John Arigo, Thomas O’Connor, Rakhi Shah   +5 more
doaj   +2 more sources

Exploratory Testing of Energy-Saving Characteristics of Large-Scale Freeze-Drying Equipment

Energies
The advantages of continuous freeze-drying are increasingly being emphasized, including energy saving, high production efficiency, and superior quality. In this context, an innovative continuous production process and cold trap structure for large-scale ...
Yiqiang Liu, Yanhua Tian, Yijian He
doaj   +2 more sources

Mechanistic Modeling of Continuous Lyophilization for Biopharmaceutical Manufacturing [PDF]

Advanced Science
Lyophilization (aka freeze drying) is a typical process in (bio)pharmaceutical manufacturing used for improving the stability of various drug products, including its recent applications to mRNA vaccines.
Prakitr Srisuma, Gang Chen, Richard D. Braatz   +2 more
doaj   +2 more sources

Current Status of Grain Drying Technology and Equipment Development: A Review [PDF]

Foods
Grain drying technology is a core process for ensuring food quality, extending storage life, and improving processing adaptability. With the continuous growth of global food demand and the increasing requirements for food quality and energy efficiency ...
Pengpeng Yu, Wenhui Zhu, Chaoping Shen, Yu Qiao, Wenya Zhang, Yansheng Zhu, Jun Gong, Jianrong Cai   +7 more
doaj   +2 more sources

Optimization of continuous spin-freeze-drying: The role of spin-freezing on quality attributes and drying efficiency of a model peptide formulation

European Journal of Pharmaceutical Sciences
Continuous spin-freeze-drying is an innovative pharmaceutical manufacturing approach offering real-time monitoring and control at the individual vial level, unlike conventional batch lyophilization. A central feature of this technology is spin-freezing, which involves rapidly spinning liquid-filled vials under a precisely controlled cold gas flow ...
Zarah Schaal, Pieter-Jan Van Bockstal, Joris Lammens, Julian H. Lenger, Adrian P. Funke, Stefan C. Schneid, Hristo L. Svilenov, Thomas De Beer   +7 more
openaire   +3 more sources

Dual chamber cartridges in a continuous pharmaceutical freeze-drying concept: Determination of the optimal dynamic infrared heater temperature during primary drying

International Journal of Pharmaceutics, 2019
The applicability of DCCs in a continuous freeze-drying concept based on spin freezing and infrared heating was evaluated. Maximum applicable filling volume was evaluated. Secondly the mechanistic model for the determination of the optimal dynamic infrared heater temperature during primary drying of regular vials during continuous freeze-drying was ...
Laurens De Meyer, Joris Lammens, Brecht Vanbillemont, Pieter Jan Van Bockstal, Jos Corver, Chris Vervaet, Wolfgang Friess, Thomas De Beer   +7 more
openaire   +3 more sources

Spin Freezing and Its Impact on Pore Size, Tortuosity and Solid State

Pharmaceutics, 2021
Spin freeze-drying, as a part of a continuous freeze-drying technology, is associated with a much higher drying rate and a higher level of process control in comparison with batch freeze-drying.
Joris Lammens, Niloofar Moazami Goudarzi, Laurens Leys, Gust Nuytten, Pieter-Jan Van Bockstal, Chris Vervaet, Matthieu N. Boone, Thomas De Beer   +7 more
doaj   +1 more source

Drying efficiency and quality preservation of blackberries (Rubus spp. variety Tupy) in the near and mid-infrared-assisted freeze-drying

Food Chemistry Advances, 2023
The influence of infrared radiation-assisted freeze-drying (IRFD) on the process efficiency and quality of blackberries (Rubus spp. variety Tupy) was evaluated.
Natália Leite Oliveira, Ana Cláudia Silveira Alexandre, Sérgio Henrique Silva, Jayne de Abreu Figueiredo, Adrise Aparecida Rodrigues, Jaime Vilela de Resende   +5 more
doaj   +1 more source