Results 51 to 60 of about 992,465 (307)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

JOTSE'S New challenges and continuous improvement

Journal of Technology and Science Education, 2020
As usual in JOTSE, the first editorial of the year presents an analysis of our Journal evolution. In this sense, we reflect on the changes just undergone and the challenges to be faced in the New Year 2020.
Beatriz Amante García, María Martínez Martínez   +1 more
doaj   +1 more source

The role of organisational motivation and coordination in continuous improvement implementations:an empirical research of process improvement project success [PDF]

, 2020
The paper aims to elicit the understanding of process improvement (PI) project success by researching the effects of organisational–motivation and coordination in continuous improvement (CI) implementations in the financial services sector.
Does, R.J.M.M., Antony, J, Garza-Reyes, Jose, Lameijer, B.A.; id_orcid, Chakraborty, A., Antony, Jiju, Garza-Reyes, J. A., Chakraborty, Ayon, Garza-Reyes, J.A., Does, R. J. M. M., Lameijer, B, Lameijer, Bart, Antony, J., Does, R.J.M.M.; id_orcid, Chakraborty, A, Does, Ronald, Lameijer, B. A.   +16 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Leveraging a multifaceted digital medication refill system on improving patients’ medication adherence and reducing medication oversupply among elderly patients with hypertension

BMJ Open Quality
The COVID-19 pandemic has disrupted healthcare, causing challenges in managing chronic diseases like hypertension. Al-Hada Armed Forces Hospital’s Pharmaceutical Care Department aims to provide safe, efficient, and effective medication refills for ...
Muhammad Hasan Abid, Bushra AL Mubarak, Lamiaa Nehad Elmasry, Matuk Qoronfulah, Bodour AlOtaibi, Dakhelullah AlOsaimy, Ammar Hawsawi, Faris AlShehri   +7 more
doaj   +1 more source

Framework for Continuous Assessment and Improvement of Occupational Health and Safety Issues in Construction Companies

Safety and Health at Work, 2014
Background: Construction industry is among the most hazardous industries, and needs a comprehensive and simple-to-administer tool to continuously assess and promote its health and safety performance. Methods: Through the study of various standard systems
Shahram Mahmoudi, Fakhradin Ghasemi, Iraj Mohammadfam, Esmaeil Soleimani   +3 more
doaj   +1 more source

Implementing continuous process improvement methods in a mid-size plastic company [PDF]

, 2006
Includes bibliographical ...
Chongwatpol, Narongsawas
core  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

A Comprehensive Review on Bigels as a Potential Replacement to Solid Fat in Food Applications

Journal of Food Quality
Bigels, composed of hydrogels and oleogels, are emerging as innovative materials with significant potential in the food industry. This review explores the application of bigels in various food contexts, including conventional and novel meats, plant-based
Wasiya Farzana, Sneha Mahesh, Sachin Sharma, Irshaan Syed, Gholamreza Abdi, Rituja Upadhyay   +5 more
doaj   +1 more source

A Comparison of Quality Improvement Methods in Health System [PDF]

Taṣvīr-i salāmat, 2013
Background and Objectives : Quality improvement is defined as improving process performance and maintaining improved results. Improvement methods and quality tools are two important factors of CQI projects.
Mostafa Farah Bakhsh
doaj