Results 11 to 20 of about 131,968 (259)

Pharma 4.0 Continuous mRNA Drug Products Manufacturing [PDF]

Pharmaceutics, 2021
Continuous mRNA drugs manufacturing is perceived to nurture flow processes featuring quality by design, controlled automation, real time validation, robustness, and reproducibility, pertaining to regulatory harmonization. However, the actual adaptation of the latter remains elusive, hence batch-to-continuous transition would a priori necessitate ...
Andreas Ouranidis, Christina Davidopoulou, Reald-Konstantinos Tashi, Kyriakos Kachrimanis   +3 more
openaire   +3 more sources

The Influence of Equipment Design and Process Parameters on Granule Breakage in a Semi-Continuous Fluid Bed Dryer after Continuous Twin-Screw Wet Granulation

Pharmaceutics, 2021
The drying unit of a continuous from-powder-to-tablet manufacturing line based on twin-screw granulation (TSG) is a crucial intermediate process step to achieve the desired tablet quality.
Alexander Ryckaert, Michael Ghijs, Christoph Portier, Dejan Djuric, Adrian Funke, Chris Vervaet, Thomas De Beer   +6 more
doaj   +1 more source

Effect of Process Conditions on Particle Size and Shape in Continuous Antisolvent Crystallisation of Lovastatin

Crystals, 2020
Lovastatin crystals often exhibit an undesirable needle-like morphology. Several studies have shown how a needle-like morphology can be modified in antisolvent crystallisation with the use of additives, but there is much less experimental work ...
John McGinty, Magdalene W. S. Chong, Andrew Manson, Cameron J. Brown, Alison Nordon, Jan Sefcik   +5 more
doaj   +1 more source

Impact of Vertical Blender Unit Parameters on Subsequent Process Parameters and Tablet Properties in a Continuous Direct Compression Line

Pharmaceutics, 2022
The continuous manufacturing of solid oral-dosage forms represents an emerging technology among the pharmaceutical industry, where several process steps are combined in one production line.
Marius J. Kreiser, Christoph Wabel, Karl G. Wagner   +2 more
doaj   +1 more source

Predictive Model-Based Process Start-Up in Pharmaceutical Continuous Granulation and Drying

Pharmaceutics, 2020
Continuous manufacturing (CM) is a promising strategy to achieve various benefits in the context of quality, flexibility, safety and cost in pharmaceutical production.
Victoria Pauli, Peter Kleinebudde, Markus Krumme   +2 more
doaj   +1 more source

Lubricant Sensitivity of Direct Compression Grades of Lactose in Continuous and Batch Tableting Process

Pharmaceutics, 2023
Modern pharmaceutical manufacturing based on Quality by Design and digitalisation is revolutionising the pharmaceutical industry. Continuous processes are promoted as they increase efficiency and improve quality control.
Gerald A. Hebbink, Pauline H. M. Janssen, Jurjen H. Kok, Lorenzo Menarini, Federica Giatti, Caterina Funaro, Salvatore Fabrizio Consoli, Bastiaan H. J. Dickhoff   +7 more
doaj   +1 more source

Nucleation and Growth Kinetics of Sodium Chloride Crystallization from Water and Deuterium Oxide

Crystals, 2023
Despite the ubiquity of the crystallization of sodium chloride (NaCl) throughout history, few detailed, well-controlled quantitative studies of the kinetics of NaCl crystallization have been published.
James M. Flannigan, Daniel MacIver, Hikaru Jolliffe, Mark D. Haw, Jan Sefcik   +4 more
doaj   +1 more source

A Novel Approach for Non-Invasive Continuous In-Line Control of Perfusion Cell Cultivations by Raman Spectroscopy

Frontiers in Bioengineering and Biotechnology, 2022
Continuous manufacturing is becoming more important in the biopharmaceutical industry. This processing strategy is favorable, as it is more efficient, flexible, and has the potential to produce higher and more consistent product quality. At the same time,
A. Graf, J. Lemke, M. Schulze, R. Soeldner, K. Rebner, M. Hoehse, J. Matuszczyk   +6 more
doaj   +1 more source

Applications of Supercritical Anti-Solvent Process in Preparation of Solid Multicomponent Systems

Pharmaceutics, 2021
Solid multicomponent systems (SMS) are gaining an increasingly important role in the pharmaceutical industry, to improve the physicochemical properties of active pharmaceutical ingredients (APIs). In recent years, various processes have been employed for
Guijin Liu, Junjian Li, Shiming Deng
doaj   +1 more source

Continuous Twin Screw Granulation: A Review of Recent Progress and Opportunities in Formulation and Equipment Design

Pharmaceutics, 2021
Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the pharmaceutical industry as well as in academia over the last ten years.
Christoph Portier, Chris Vervaet, Valérie Vanhoorne   +2 more
doaj   +1 more source