Results 21 to 30 of about 768,012 (158)

Real-time assessment of critical quality attributes of a continuous granulation process [PDF]

, 2013
There exists the intention to shift pharmaceutical manufacturing of solid dosage forms from traditional batch production towards continuous production. The currently applied conventional quality control systems, based on sampling and time-consuming off ...
Córdoba Díaz, Damián, De Beer, Thomas, Fonteyne, Margot, Gildemyn, Delphine, Remon, Jean Paul, Vercruysse, Jurgen, Vervaet, Chris   +6 more
core   +1 more source

Continuous Isolation of Particles with Varying Aspect Ratios up to Thin Needles Achieving Free-Flowing Products

Crystals, 2022
The continuous vacuum screw filter (CVSF) for small-scale continuous product isolation of suspensions was operated for the first time with cuboid-shaped and needle-shaped particles.
Claas Steenweg, Jonas Habicht, Kerstin Wohlgemuth   +2 more
doaj   +1 more source

Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing

Pharmaceutics, 2023
The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process.
Seth P. Forster, Erin Dippold, Abbe Haser, Daniel Emanuele, Robin Meier   +4 more
doaj   +1 more source

Extrusion - back to the future: using an established technique to reform automated chemical synthesis [PDF]

, 2016
YesHerein, the benefits which extrusion can provide for the automated continuous synthesis of organic compounds are highlighted. Extrusion is a well-established technique that has a vital role in the manufacturing processes of polymers, pharmaceuticals ...
Crawford, Deborah E.
core   +2 more sources

A hybrid system of mixture models for the prediction of particle size and shape, density, and flowability of pharmaceutical powder blends

International Journal of Pharmaceutics: X
This paper presents a system of hybrid models that combine both mechanistic and data-driven approaches to predict physical powder blend properties from their raw component properties.
Mohammad Salehian, Jonathan Moores, Jonathan Goldie, Isra' Ibrahim, Carlota Mendez Torrecillas, Ishwari Wale, Faisal Abbas, Natalie Maclean, John Robertson, Alastair Florence, Daniel Markl   +10 more
doaj   +1 more source

Process intensification for lentiviral vector manufacturing using tangential flow depth filtration

Molecular Therapy: Methods & Clinical Development, 2023
For gene therapies to become more accessible and affordable treatment options, process intensification is one possible strategy to increase the number of doses generated per batch of viral vector.
Robert M. Tona, Reeti Shah, Kimberly Middaugh, Justin Steve, João Marques, Blair R. Roszell, Cindy Jung   +6 more
doaj   +1 more source

Key Fabrications of Chitosan Nanoparticles for Effective Drug Delivery Using Flow Chemistry Reactors

International Journal of Nanomedicine, 2023
Kampanart Huanbutta,1 Pornsak Sriamornsak,2,3 Kittipat Suwanpitak,4 Nattapat Klinchuen,4 Thanapat Deebugkum,4 Vasanchai Teppitak,4 Tanikan Sangnim4 1Department of Manufacturing Pharmacy, College of Pharmacy, Rangsit University, Pathum Thani, 12000 ...
Huanbutta K, Sriamornsak P, Suwanpitak K, Klinchuen N, Deebugkum T, Teppitak V, Sangnim T   +6 more
doaj  

End-to-End Continuous Small-Scale Drug Substance Manufacturing: From a Continuous In Situ Nucleator to Free-Flowing Crystalline Particles

Crystals, 2023
In the evolving landscape of pharmaceutical manufacturing, a comprehensive continuous production process is being crafted for the small-scale production of active pharmaceutical ingredients.
Anne Cathrine Kufner, Marc Meier, Kerstin Wohlgemuth   +2 more
doaj   +1 more source

LEAN MANUFACTURING TOOLS AND TECHNIQUES IN THE PROCESS INDUSTRY WITH A FOCUS ON STEEL [PDF]

, 2003
This research addresses the application of lean manufacturing concepts to the continuous production/ process sector with a focus on the steel industry.
Fawaz Abdullah, Fawaz Abdullah Phd
core   +1 more source

Improvement of a 1D Population Balance Model for Twin-Screw Wet Granulation by Using Identifiability Analysis

Pharmaceutics, 2021
Recently, the pharmaceutical industry has undergone changes in the production of solid oral dosages from traditional inefficient and expensive batch production to continuous manufacturing.
Ana Alejandra Barrera Jiménez, Daan Van Hauwermeiren, Michiel Peeters, Thomas De Beer, Ingmar Nopens   +4 more
doaj   +1 more source