Results 11 to 20 of about 768,012 (158)

Continuous Pharmaceutical Manufacturing [PDF]

Pharmaceutics, 2020
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Ossi Korhonen
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A Novel Approach for Non-Invasive Continuous In-Line Control of Perfusion Cell Cultivations by Raman Spectroscopy

Frontiers in Bioengineering and Biotechnology, 2022
Continuous manufacturing is becoming more important in the biopharmaceutical industry. This processing strategy is favorable, as it is more efficient, flexible, and has the potential to produce higher and more consistent product quality. At the same time,
A. Graf, J. Lemke, M. Schulze, R. Soeldner, K. Rebner, M. Hoehse, J. Matuszczyk   +6 more
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Applications of Supercritical Anti-Solvent Process in Preparation of Solid Multicomponent Systems

Pharmaceutics, 2021
Solid multicomponent systems (SMS) are gaining an increasingly important role in the pharmaceutical industry, to improve the physicochemical properties of active pharmaceutical ingredients (APIs). In recent years, various processes have been employed for
Guijin Liu, Junjian Li, Shiming Deng
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Continuous direct compression as manufacturing platform for sustained release tablets [PDF]

, 2017
This study presents a framework for process and product development on a continuous direct compression manufacturing platform. A challenging sustained release formulation with high content of a poorly flowing low density drug was selected.
Cunningham, C., De Beer, Thomas, Holman, J., Kumar, Ashish, Remon, Jean Paul, Van Snick, Bernd, Vercruysse, Jurgen, Vervaet, Chris   +7 more
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Continuous Twin Screw Granulation: A Review of Recent Progress and Opportunities in Formulation and Equipment Design

Pharmaceutics, 2021
Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the pharmaceutical industry as well as in academia over the last ten years.
Christoph Portier, Chris Vervaet, Valérie Vanhoorne   +2 more
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An Automated Continuous Synthesis and Isolation for the Scalable Production of Aryl Sulfonyl Chlorides

Molecules, 2023
In this work, a continuous system to produce multi-hundred-gram quantities of aryl sulfonyl chlorides is described. The scheme employs multiple continuous stirred-tank reactors (CSTRs) and a continuous filtration system and incorporates an automated ...
Matthew Glace, Cameron Armstrong, Nathan Puryear, Colin Bailey, Roudabeh Sadat Moazeni-Pourasil, Drew Scott, Sherif Abdelwahed, Thomas. D. Roper   +7 more
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Manufacturing System Lean Improvement Design Using Discrete Event Simulation [PDF]

, 2016
Lean manufacturing (LM) has been used widely in the past for the continuous improvement of existing production systems. A Lean Assessment Tool (LAT) is used for assessing the overall performance of lean practices within a system, while a Discrete Event ...
Omogbai, Oleghe, Salonitis, Konstantinos
core   +1 more source

Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process

Pharmaceutics, 2021
The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely
Lise Vandevivere, Maxine Vangampelaere, Christoph Portier, Cedrine de Backere, Olaf Häusler, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne   +7 more
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Development and Use of a Residence Time Distribution (RTD) Model Control Strategy for a Continuous Manufacturing Drug Product Pharmaceutical Process

Pharmaceutics, 2022
Residence-time-distribution (RTD)-based models are key to understanding the mixing dynamics of continuous manufacturing systems. Such models can allow for material traceability throughout the process and can provide the ability for removal of non ...
Samantha Hurley, Anthony Tantuccio, Manuel Sebastian Escotet-Espinoza, Matthew Flamm, Matthew Metzger   +4 more
doaj   +1 more source

On electrical load tracking scheduling for a steel plant [PDF]

, 2010
Nolde and Morari (2010) study a steel manufacturing scheduling problem where the tasks must be scheduled such that electricity consumption matches to a pre-specified periodic energy chart.
Artigues, Christian, Haït, Alain
core   +3 more sources