Results 31 to 40 of about 5,232,603 (249)

A Novel Approach for Non-Invasive Continuous In-Line Control of Perfusion Cell Cultivations by Raman Spectroscopy

Frontiers in Bioengineering and Biotechnology, 2022
Continuous manufacturing is becoming more important in the biopharmaceutical industry. This processing strategy is favorable, as it is more efficient, flexible, and has the potential to produce higher and more consistent product quality. At the same time,
A. Graf, J. Lemke, M. Schulze, R. Soeldner, K. Rebner, M. Hoehse, J. Matuszczyk   +6 more
doaj   +1 more source

Applications of Supercritical Anti-Solvent Process in Preparation of Solid Multicomponent Systems

Pharmaceutics, 2021
Solid multicomponent systems (SMS) are gaining an increasingly important role in the pharmaceutical industry, to improve the physicochemical properties of active pharmaceutical ingredients (APIs). In recent years, various processes have been employed for
Guijin Liu, Junjian Li, Shiming Deng
doaj   +1 more source

Continuous Twin Screw Granulation: A Review of Recent Progress and Opportunities in Formulation and Equipment Design

Pharmaceutics, 2021
Continuous twin screw wet granulation is one of the key continuous manufacturing technologies that have gained significant interest in the pharmaceutical industry as well as in academia over the last ten years.
Christoph Portier, Chris Vervaet, Valérie Vanhoorne   +2 more
doaj   +1 more source

An Automated Continuous Synthesis and Isolation for the Scalable Production of Aryl Sulfonyl Chlorides

Molecules, 2023
In this work, a continuous system to produce multi-hundred-gram quantities of aryl sulfonyl chlorides is described. The scheme employs multiple continuous stirred-tank reactors (CSTRs) and a continuous filtration system and incorporates an automated ...
Matthew Glace, Cameron Armstrong, Nathan Puryear, Colin Bailey, Roudabeh Sadat Moazeni-Pourasil, Drew Scott, Sherif Abdelwahed, Thomas. D. Roper   +7 more
doaj   +1 more source

Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process

Pharmaceutics, 2021
The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely
Lise Vandevivere, Maxine Vangampelaere, Christoph Portier, Cedrine de Backere, Olaf Häusler, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne   +7 more
doaj   +1 more source

Learning from the future: towards continuous manufacturing of nanomaterials

AAPS Open
The rise of continuous manufacturing (CM) in the pharmaceutical industry – particularly for the solid oral dosage form—marks a major shift in how drugs are made.
Michael A. VandenBerg, Xiang Dong, William C. Smith, Geng Tian, Olen Stephens, Thomas F. O’Connor, Xiaoming Xu   +6 more
semanticscholar   +1 more source

Data-driven model predictive control for pharmaceutical continuous manufacturing.

International journal of pharmaceutics
This study demonstrates that developing interpretable, data-driven models for pharmaceutical continuous manufacturing is feasible using a machine learning method called Dynamic Mode Decomposition with Control (DMDc).
Consuelo Vega-Zambrano, N. A. Diangelakis, Vassilis M. Charitopoulos   +2 more
semanticscholar   +1 more source

A hybrid system of mixture models for the prediction of particle size and shape, density, and flowability of pharmaceutical powder blends

International Journal of Pharmaceutics: X
This paper presents a system of hybrid models that combine both mechanistic and data-driven approaches to predict physical powder blend properties from their raw component properties.
Mohammad Salehian, Jonathan Moores, Jonathan Goldie, Isra' Ibrahim, Carlota Mendez Torrecillas, Ishwari Wale, Faisal Abbas, Natalie Maclean, John Robertson, Alastair Florence, Daniel Markl   +10 more
doaj   +1 more source

Establishing an Apheresis Medicine Program in a Resource‐Constrained Setting: A 5‐Year Experience From Lagos, Nigeria

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Establishing a comprehensive apheresis medicine program in a resource‐constrained setting presents significant structural, financial, and logistical challenges. Despite the growing clinical importance of apheresis services globally, published experience from sub‐Saharan Africa remains sparse.
Folasade Adelekan‐Popoola, Shakirat Gold‐Olufadi, Olufunto Olufela Kalejaiye, Abdullateef Ogala, Rasheed A. Balogun   +4 more
wiley   +1 more source

Key Fabrications of Chitosan Nanoparticles for Effective Drug Delivery Using Flow Chemistry Reactors

International Journal of Nanomedicine, 2023
Kampanart Huanbutta,1 Pornsak Sriamornsak,2,3 Kittipat Suwanpitak,4 Nattapat Klinchuen,4 Thanapat Deebugkum,4 Vasanchai Teppitak,4 Tanikan Sangnim4 1Department of Manufacturing Pharmacy, College of Pharmacy, Rangsit University, Pathum Thani, 12000 ...
Huanbutta K, Sriamornsak P, Suwanpitak K, Klinchuen N, Deebugkum T, Teppitak V, Sangnim T   +6 more
doaj