Results 21 to 30 of about 131,968 (259)

Continuous Additive Manufacturing using Olefin Metathesis

Advanced Science, 2022
AbstractThe development of chemistry is reported to implement selective dual‐wavelength olefin metathesis polymerization for continuous additive manufacturing (AM). A resin formulation based on dicyclopentadiene is produced using a latent olefin metathesis catalyst, various photosensitizers (PSs) and photobase generators (PBGs) to achieve efficient ...
Jeffrey C. Foster, Adam W. Cook, Nicolas T. Monk, Brad H. Jones, Leah N. Appelhans, Erica M. Redline, Samuel C. Leguizamon   +6 more
openaire   +3 more sources

An Automated Continuous Synthesis and Isolation for the Scalable Production of Aryl Sulfonyl Chlorides

Molecules, 2023
In this work, a continuous system to produce multi-hundred-gram quantities of aryl sulfonyl chlorides is described. The scheme employs multiple continuous stirred-tank reactors (CSTRs) and a continuous filtration system and incorporates an automated ...
Matthew Glace, Cameron Armstrong, Nathan Puryear, Colin Bailey, Roudabeh Sadat Moazeni-Pourasil, Drew Scott, Sherif Abdelwahed, Thomas. D. Roper   +7 more
doaj   +1 more source

Identifying Critical Binder Attributes to Facilitate Binder Selection for Efficient Formulation Development in a Continuous Twin Screw Wet Granulation Process

Pharmaceutics, 2021
The suitability of pharmaceutical binders for continuous twin-screw wet granulation was investigated as the pharmaceutical industry is undergoing a switch from batch to continuous manufacturing. Binder selection for twin-screw wet granulation should rely
Lise Vandevivere, Maxine Vangampelaere, Christoph Portier, Cedrine de Backere, Olaf Häusler, Thomas De Beer, Chris Vervaet, Valérie Vanhoorne   +7 more
doaj   +1 more source

Developments and opportunities in continuous biopharmaceutical manufacturing [PDF]

mAbs, 2021
Today's biologics manufacturing practices incur high costs to the drug makers, which can contribute to high prices for patients. Timely investment in the development and implementation of continuous biomanufacturing can increase the production of consistent-quality drugs at a lower cost and a faster pace, to meet growing demand.
Ohnmar Khanal, Abraham M. Lenhoff
openaire   +3 more sources

Continuous Isolation of Particles with Varying Aspect Ratios up to Thin Needles Achieving Free-Flowing Products

Crystals, 2022
The continuous vacuum screw filter (CVSF) for small-scale continuous product isolation of suspensions was operated for the first time with cuboid-shaped and needle-shaped particles.
Claas Steenweg, Jonas Habicht, Kerstin Wohlgemuth   +2 more
doaj   +1 more source

Integrated Continuous Wet Granulation and Drying: Process Evaluation and Comparison with Batch Processing

Pharmaceutics, 2023
The pharmaceutical industry is in the midst of a transition from traditional batch processes to continuous manufacturing. However, the challenges in making this transition vary depending on the selected manufacturing process.
Seth P. Forster, Erin Dippold, Abbe Haser, Daniel Emanuele, Robin Meier   +4 more
doaj   +1 more source

Process intensification for lentiviral vector manufacturing using tangential flow depth filtration

Molecular Therapy: Methods & Clinical Development, 2023
For gene therapies to become more accessible and affordable treatment options, process intensification is one possible strategy to increase the number of doses generated per batch of viral vector.
Robert M. Tona, Reeti Shah, Kimberly Middaugh, Justin Steve, João Marques, Blair R. Roszell, Cindy Jung   +6 more
doaj   +1 more source

A hybrid system of mixture models for the prediction of particle size and shape, density, and flowability of pharmaceutical powder blends

International Journal of Pharmaceutics: X
This paper presents a system of hybrid models that combine both mechanistic and data-driven approaches to predict physical powder blend properties from their raw component properties.
Mohammad Salehian, Jonathan Moores, Jonathan Goldie, Isra' Ibrahim, Carlota Mendez Torrecillas, Ishwari Wale, Faisal Abbas, Natalie Maclean, John Robertson, Alastair Florence, Daniel Markl   +10 more
doaj   +1 more source

End-to-End Continuous Small-Scale Drug Substance Manufacturing: From a Continuous In Situ Nucleator to Free-Flowing Crystalline Particles

Crystals, 2023
In the evolving landscape of pharmaceutical manufacturing, a comprehensive continuous production process is being crafted for the small-scale production of active pharmaceutical ingredients.
Anne Cathrine Kufner, Marc Meier, Kerstin Wohlgemuth   +2 more
doaj   +1 more source

Key Fabrications of Chitosan Nanoparticles for Effective Drug Delivery Using Flow Chemistry Reactors

International Journal of Nanomedicine, 2023
Kampanart Huanbutta,1 Pornsak Sriamornsak,2,3 Kittipat Suwanpitak,4 Nattapat Klinchuen,4 Thanapat Deebugkum,4 Vasanchai Teppitak,4 Tanikan Sangnim4 1Department of Manufacturing Pharmacy, College of Pharmacy, Rangsit University, Pathum Thani, 12000 ...
Huanbutta K, Sriamornsak P, Suwanpitak K, Klinchuen N, Deebugkum T, Teppitak V, Sangnim T   +6 more
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