Results 31 to 40 of about 131,968 (259)
Pharmaceutics, 2021 Recently, the pharmaceutical industry has undergone changes in the production of solid oral dosages from traditional inefficient and expensive batch production to continuous manufacturing.
Ana Alejandra Barrera Jiménez +4 more
doaj +1 more source
FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Assessing distortion in carbon fiber woven fabrics based on machine vision
Advanced Manufacturing: Polymer & Composites ScienceDistortion in carbon fiber woven fabrics significantly impacts composite mechanical performance through defective fiber tow distribution. This work proposes a machine vision method to locate defective areas, identify defects, and describe fiber tow ...
Shiyue Li, Quanzhou Yao, Lin Ye
doaj +1 more source
A NIR-Based Study of Desorption Kinetics during Continuous Spin Freeze-Drying
Pharmaceutics, 2021 The pharmaceutical industry is progressing toward the development of more continuous manufacturing techniques. At the same time, the industry is striving toward more process understanding and improved process control, which requires the implementation of
Laurens Leys +6 more
doaj +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
MicromachinesThe print head is one of the most critical components in an additive manufacturing (AM) system. It can significantly affect the quality of printed parts.
Heng Cai, Yuan Chen
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Self‐Driven Multistep Quantum Dot Synthesis Enabled by Autonomous Robotic Experimentation in Flow
Advanced Intelligent Systems, 2021 Identifying the optimal formulation of emerging inorganic lead halide perovskite quantum dots (LHP QDs) with their vast colloidal synthesis universe and multiple synthesis/postsynthesis processing parameters is a challenging undertaking for material‐ and
Kameel Abdel-Latif +5 more
doaj +1 more source