Results 51 to 60 of about 522,687 (294)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Phase fluorometry using a continuously modulated laser diode [PDF]

Analytical Chemistry, 1992
The authors report phase fluorometrlc measurements using directly amplitude-modulated 670- and 791-nm laser diodes as the excitation source. Fluorescence lifetimes ranging from 220 ps to 1.7 ns were measured using a commercial phase fluorometer. It was found that higher amounts of radio frequency power were required to achieve comparable degrees of ...
Richard B, Thompson, Joan K, Frisoli, Joseph R, Lakowicz   +2 more
openaire   +2 more sources

A fast Maximum Likelihood method for improving AMCW lidar precision using waveform shape [PDF]

, 2009
Amplitude Modulated Continuous Wave imaging lidar systems use the time-of-flight principle to determine the range to objects in a scene. Typical systems use modulated illumination of a scene and a modulated sensor or image intensifier.
Cree, Michael J., Dorrington, Adrian A., Godbaz, John Peter, Payne, Andrew D.   +3 more
core   +2 more sources

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Modulation instability, Akhmediev Breathers and continuous wave supercontinuum generation

, 2009
Numerical simulations of the onset phase of continuous wave supercontinuum generation from modulation instability show that the structure of the field as it develops can be interpreted in terms of the properties of Akhmediev Breathers.
Ablowitz, Agrawal, Akhmediev, Akhmediev, Akhmediev, Akhmediev, Akhmediev, B. Kibler, Barviau, Beeckman, Benjamin, Bespalov, Cruz, Demircan, Dudley, Dudley, Dudley, Dudley, Dysthe, F. Dias, G. Genty, Genty, Greer, Hart, Inoue, J. M. Dudley, Karpman, Kobtsev, Korneev, Kutz, Liu, N. Akhmediev, Osborne, Ranka, Solli, Solli, Tai, Travers, Trillo, Trillo, Van Simaeys, Voronovich   +41 more
core   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Self-referencing a continuous-wave laser with electro-optic modulation [PDF]

, 2015
We phase-coherently measure the frequency of continuous-wave (CW) laser light by use of optical-phase modulation and f-2f nonlinear interferometry. Periodic electro-optic modulation (EOM) transforms the CW laser into a continuous train of picosecond ...
Beha, Katja, Coillet, Aurélien, Cole, Daniel C., Del'Haye, Pascal, Diddams, Scott A., Papp, Scott B.   +5 more
core   +2 more sources

Unidimensional continuous-variable quantum key distribution

, 2015
We propose the continuous-variable quantum key distribution protocol based on the Gaussian modulation of a single quadrature of the coherent states of light, which is aimed to provide simplified implementation compared to the symmetrically modulated ...
Grosshans, Frédéric, Usenko, Vladyslav C.   +1 more
core   +3 more sources

Nonclassical correlations of phase noise and photon number in quantum nondemolition measurements [PDF]

, 1999
The continuous transition from a low resolution quantum nondemolition measurement of light field intensity to a precise measurement of photon number is described using a generalized measurement postulate.
A.E. Siegmann, D.T. Pegg, E. Schrödinger, E. Schrödinger, E. Schrödinger, Holger F. Hofmann, J. von Neumann, J.S. Bell, L. Susskind, M. Beller, M. Brune, M. Kitagawa, M.D. Levenson, M.J. Holland, N. Imoto, N.D. Mermin, S. Goldstein, S. Goldstein, S. Goldstein, S.R. Friberg, W. Heisenberg, Y. Yamamoto   +21 more
core   +4 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source