Results 61 to 70 of about 522,687 (294)
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Estimation of Modulation Index for Partial Response CPM Signal
IEEE Access, 2018 Continuous phase modulation (CPM) is a power and bandwidth efficient modulation scheme used in cellular, personal, and satellite communications among other applications.
Tayyaba Munawar +3 more
doaj +1 more source
Electrical Phase Control Based on Graphene Surface Plasmon Polaritons in Mid-infrared
Nanomaterials, 2020 Phase modulation of light is the core of many optoelectronic applications, such as electro-optic switch, sensors and modulators. Graphene Surface plasmon polaritons (SPPs) exhibit unique properties in phase modulation including dynamic tunability, a ...
Yindi Wang +5 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
PSWF signal based continuous phase modulation and its spectrum performance analysis
Dianxin kexue, 2020 Prolate spheroidal wave function (PSWF) signals are the best energy-gathering signals in the time-frequency domain,here is an exploratory application of PSWF signals to continuous phase modulation technology.Firstly,the process of generating CPM ...
Dawei YANG, Chuanhui LIU, Jiafang KANG
doaj +2 more sources
Applied Sciences, 2020 Here we theoretically and experimentally demonstrated the arbitrary phase modulation of a general transmittance function (GTF) of the first-order optical comb filter based on a polarization-diversity loop structure, which employed two ordered waveplate ...
Jaehoon Jung, Yong Wook Lee
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
IEEE Photonics JournalThe output power of fiber lasers with narrow-linewidth is typically limited by stimulated Brillouin scattering (SBS). Spectral broadening via phase modulation is preferred to suppress SBS, but its capability approaches the limit for a given linewidth and
Mengqi Zhang +8 more
doaj +1 more source