Results 121 to 130 of about 11,782,726 (286)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Sampled-data H∞ˆž-control for time-varying hybrid systems

, 2001
This paper presents sampled-data H∞ˆž-control of linear mixed continuous-time and discrete-time systems, including a mix of continuous-time and discrete-time performance signals and disturbances.
Lennartson, Bengt,, Toivonen, H.T.,, Christiansson, Anna-Karin,   +2 more
core  

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Towards more effective testing of communications-critical large scale systems [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.A publication based on the research from this thesis has been published and can be cited as Nabulsi, MA and Hierons, RM (2014), A new test framework for ...
Nabulsi, Mohammad
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

When New Product Development Is Not Enough for Sustained Performance: An Empirical Validation of “The Continuous Innovation Stool” [PDF]

, 2018
Hyland and Boer (2006) introduce the “continuous innovation stool”, describing continuous innovation in terms of operational, innovation and strategic capabilities.
Corso, Mariano, Boer, Henrike Engele Elisabeth, Neirotti, Paolo, Boer, Harry; id_orcid, Boer, Henrike, Boer, Harry, Gastaldi, Luca   +6 more
core  

Data on likelihood ratios of two-person DNA mixtures interpreted using semi- and fully continuous systems. [PDF]

Data Brief, 2019
Rodriguez JJRB, Bright JA, Salvador JM, Laude RP, De Ungria MCA.   +4 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

The General Solution of Singular Fractional-Order Linear Time-Invariant Continuous Systems with Regular Pencils. [PDF]

Entropy (Basel), 2018
Batiha IM, El-Khazali R, AlSaedi A, Momani S.   +3 more
europepmc   +1 more source