Results 141 to 150 of about 11,782,726 (286)

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Nonlinear Vibration of Continuous Systems

Shock and Vibration, 2019
Francesco Pellicano, Matteo Strozzi, Konstantin V. Avramov   +2 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Insights into Flow and Continuous Systems in Pharmaceutical Manufacturing: Challenges and Opportunities. [PDF]

Org Process Res Dev
Daly AM, Hardiman S, Hogan D, Morris G, Moylan R, O'Donovan B, Power E, Phillips P, Robinson S, Roth PMC, Smyth M, Magner E, Arthur A, McGlacken GP, Baumann M, Maguire AR.   +15 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

H∞ output feedback control for two-dimensional continuous systems

, 2008
This paper is concerned with the problem of H∞ control for two-dimensional (2-D) continuous systems described by the Roesser state space model. Attention is focused on the design of full-order dynamic output feedback controllers which not only stabilize ...
Zou, Y, Lam, J, Galkowski, K, Xu, S, Lin, Z   +4 more
core  

Adsorptive removal of azithromycin from aqueous solution using flake-like Co-ZIF coated melamine sponge in batch and continuous systems. [PDF]

Sci Rep
Adashi A, Mazloom G, Ghani M, Banisharif F.   +3 more
europepmc   +1 more source

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Acetaminophen and Tetracycline Removal Using <i>Prosopis juliflora</i>-Derived ZnO-Modified Biochar: Evaluation in Batch and Continuous Systems. [PDF]

ACS Omega
Singanodi Vallabha M, Asma SR, Reddy R, Mohan B, Girish CR.   +4 more
europepmc   +1 more source

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source