Results 71 to 80 of about 31,694,594 (321)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Symbolic models for nonlinear control systems affected by disturbances

open access: yes, 2012
In the last few years there has been a growing interest in the use of symbolic models for the formal verification and control design of purely continuous or hybrid systems.
Borri, Alessandro   +2 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

E_0-Semigroups for Continuous Product Systems

open access: yes, 2006
We show that every continuous product system of correspondences over a unital C*-algebra occurs as the product system of a strictly continuous E_0 ...
Skeide, Michael
core   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

open access: yesFEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas   +3 more
wiley   +1 more source

Quantum fluctuations in quantum lattice-systems with continuous symmetry

open access: yes, 1996
We discuss conditions for the absence of spontaneous breakdown of continuous symmetries in quantum lattice systems at $T=0$. Our analysis is based on Pitaevskii and Stringari's idea that the uncertainty relation can be employed to show quantum ...
A. Klein   +29 more
core   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Alternate-continuous-control systems with double-impulse

open access: yesAdvances in Difference Equations, 2017
We propose a mathematical model that can control the stability of an unstable system. Periodicity is an important feature of the system. We add a continuous control to the first half of each period of the system and then add an impulse control J1 at the ...
Xiang Hu   +3 more
doaj   +1 more source

Continuous Systems

open access: yes
Abstract Applying Newton's second law to the rod element the linear damping involved in the rod element. The above equation can be written as.
Zeng He, Wen Jiang, Lin Wang
openaire   +2 more sources

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