Results 81 to 90 of about 31,694,594 (321)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Stability of Continuous Time Difference Systems

Abstract and Applied Analysis
We propose new sufficient conditions for the exponential stability of a class of nonlinear delay difference equations with continuous time (DECT). The above conditions provide a direct estimation of the exponential decay rate of the system.
Rigoberto Medina
doaj   +1 more source

Indefinite causal structures for continuous-variable systems

New Journal of Physics, 2016
In all our well-established theories, it is assumed that events are embedded in a global causal structure such that, for every pair of events, the causal order between them is always fixed.
Flaminia Giacomini, Esteban Castro-Ruiz, Časlav Brukner   +2 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Second Order Krotov Method for Discrete-Continuous Systems

Известия Иркутского государственного университета: Серия "Математика", 2020
In the late 1960s and early 1970s, a new class of problems appeared in the theory of optimal control. It was determined that the structure of a number of systems or processes is not homogeneous and can change over time. Therefore, new mathematical models
I.V. Rasina, O. V. Danilenko
doaj   +1 more source

Continuous Monitoring of Dynamical Systems and Master Equations

, 2012
We illustrate the equivalence between the non-unitary evolution of an open quantum system governed by a Markovian master equation and a process of continuous measurements involving this system.
A.R. Bosco de Magalhães, Ballentine, Bosco de Magalhães, Facchi, Facchi, Franson, Gambetta, Harris, Harris, Huang, Itano, Itano, J.G. Peixoto de Faria, Kubo, L.F. Lopes Oliveira, M.C. Nemes, Maniscalco, Maniscalco, Misra, Pascazio, Power, R. Rossi, Raimond, Rossi, Rossi, Schlosshauer, Simonius, Zurek   +27 more
core   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Integral Input-to-State Stability of Nonlinear Time-Delay Systems with Delay-Dependent Impulse Effects

, 2020
This paper studies integral input-to-state stability (iISS) of nonlinear impulsive systems with time-delay in both the continuous dynamics and the impulses. Several iISS results are established by using the method of Lyapunov-Krasovskii functionals.
Zhang, Kexue
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source