Results 111 to 120 of about 20,364 (303)
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
, 1997 We introduce the contour spectrum, a user interface component that improves qualitative user interaction and provides real-time exact quantification in the visualization of isocontours.
Schikore, Daniel R. +5 more
core +1 more source
Contour integral numerical method for the generalized eigenvalue problem of Boltzmann-BGK equation
四川大学学报. 自然科学版In this paper， a numerical method based on the contour integral is proposed for the generalized eigenvalue problem （GEP） of Boltzmann-BGK equation in linear stability analysis.In this method， a typical GEP is firstly constructed by discretizing the ...
YAO Rui-Nan +3 more
doaj
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
A SUPER ZERO-REST-MASS-EQUATION [PDF]
Journal of Sciences, Islamic Republic of Iran, 1990 Various authors have considered the Zero-rest-mass equation and the contour integral representation of its solutions. Ferber generalized these equations to supertwistor spaces with 2N odd components so that with N=O we get the standard ungraded twistors ...
doaj
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Structural Mechanics of Engineering Constructions and Buildings, 2012 Solving a problem of stress concentration around the contour of holes under different loads in anisotropic medium based on boundary integral approach is presented in this paper.
J N Nizomov, A A Hojiboe, O A Hojiboev
doaj
New Bilateral Type Generating Function Associated with I-Function
Abstract and Applied Analysis, 2014 We aim at establishing a new bilateral type generating function associated with the I-function and a Mellin-Barnes type of contour integral. The results derived here are of general character and can yield a number of (known and new) results in the theory
Praveen Agarwal +2 more
doaj +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source