Results 81 to 90 of about 226,240 (293)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

On some Noetherian criteria for singular integral operators with bounded coefficients

Acta et Commentationes: Ştiinţe Exacte şi ale Naturii
In this paper, Noetherian conditions are established for singular integral operators with measurable and bounded coefficients. The study is carried out in spaces of integrable functions with certain weights, and the integration contour is assumed to be ...
Vasile Neagu
doaj   +1 more source

Local Spacetime Physics from the Grassmannian

, 2010
A duality has recently been conjectured between all leading singularities of n-particle N^(k-2)MHV scattering amplitudes in N=4 SYM and the residues of a contour integral with a natural measure over the Grassmannian G(k,n).
A Brandhuber, A Gorsky, A Gorsky, C Cheung, E Witten, F Cachazo, F Cachazo, F Cachazo, F. Cachazo, GP Korchemsky, J Kaplan, J. Bourjaily, J. Trnka, JM Drummond, JM Drummond, JM Drummond, JM Drummond, JM Drummond, K Risager, L Dolan, LF Alday, LJ Mason, LJ Mason, M Bullimore, M Spradlin, N Arkani-Hamed, N Arkani-Hamed, N Arkani-Hamed, N Arkani-Hamed, N Arkani-Hamed, N Berkovits, N. Arkani-Hamed, P Mansfield, R Boels, R Britto, R Britto, R Roiban   +36 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Free-Boundary Seepage from Asymmetric Soil Channels

International Journal of Mathematics and Mathematical Sciences, 2012
We present an inverse method for the study of the seepage from soil channels without lining. We give integral representations of the complex potential, velocity field, stream lines, free phreatic lines, and contour of the channel by means of Levi-Civitá ...
Adrian Carabineanu
doaj   +1 more source

Product integrals II: Contour integrals

Journal of Functional Analysis, 1978
AbstractThis paper continues the joint work of the authors begun in the article “On Strong Product Integration” [J. Functional Analysis, submitted]. We consider product integrals along contours; the point of view and development is analogous to the usual complex variable theory of ordinary contour integrals.
Friedman, Charles N, Dollard, John D
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

On approximate solution of non-elliptic singular integral equation systems in Lebesgue spaces [PDF]

Computer Science Journal of Moldova, 2000
We investigate in this paper problems of theoretical foundation of collocations and mechanical quadratures methods for approximate solution of singular integral equation systems in the case, when their symbols have on the integration contour a finite set
T. Cibotaru
doaj  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source