Results 51 to 60 of about 11,746 (198)

Inflammation‐driven variability in drug metabolism: Insights from voriconazole treatment of HSCT recipients

British Journal of Clinical Pharmacology, EarlyView.
Aims Voriconazole is commonly used to prevent fungal infections after haematopoietic stem cell transplantation (HSCT). Although its metabolism is influenced by CYP2C19 genetics and inflammation, their combined effect is rarely considered in clinical practice, and integrated analyses remain limited.
Sylvia D. Klomp, Martijn L. Manson, Henk‐Jan Guchelaar, Stefan Böhringer, Esther H. M. van Egmond, Peter A. von dem Borne, Jesse J. Swen   +6 more
wiley   +1 more source

The evolving therapeutic landscape of spinal muscular atrophy – A scoping review of investigational agents, emerging delivery technologies and strategic innovations

British Journal of Clinical Pharmacology, EarlyView.
Spinal muscular atrophy (SMA) is a severe neuromuscular disease with emerging therapeutic complexity. This review aims to systematically map the global pipeline of investigational treatments for SMA. Using ClinicalTrials.gov and complementary international registries, we identified 21 planned or ongoing interventional trials from 2020 to 2025 targeting
Andrej Belančić, Patrick Eustaquio, Elvira Meni Maria Gkrinia, Ivana Stević, Eugen Javor, Yun Wah Lam, Slobodan Janković, Dinko Vitezić   +7 more
wiley   +1 more source

Double‐vestibular incision subperiosteal tunnel access (double‐VISTA) with connective tissue graft for treating multiple gingival recessions: 2‐year follow‐up

Clinical Advances in Periodontics, EarlyView.
Abstract Background Gingival recession has a multifactorial etiology, involving various predisposing and precipitating factors. Non‐carious cervical lesions (NCCLs) are often associated with gingival recession and pose challenges due to their complex pathodynamics.
Guo‐Hao Lin
wiley   +1 more source

Intraosseous sarcoidosis imitating peri‐implantitis: A case study

Clinical Advances in Periodontics, EarlyView.
Abstract Background Sarcoidosis is a multisystem granulomatous disorder of unknown cause, typically affecting the lungs and lymph nodes, but it can also involve the eyes, skin, heart, bones, and other organs. The exact cause is unclear, but genetic factors and environmental triggers like infections, chemicals, or dust may play a role.
Magdalena Orlowska, David S. Gottlieb, Kenneth S. Kornman   +2 more
wiley   +1 more source

Impaired healing following implant placement surgery: A case report of a modern‐day manifestation of scurvy

Clinical Advances in Periodontics, EarlyView.
Abstract Background Delayed wound healing following implant placement surgery is an uncommon complication, usually attributed to systemic (smoking and alcohol), local (severely inflamed tissues), or technical (poor suturing) factors. However, delayed wound healing after implant placement caused by severe hypovitaminosis C has not been previously ...
Gregor‐Georg Zafiropoulos, Gerald Kolb, Dimitris N. Tatakis   +2 more
wiley   +1 more source

Assessment of the antifertility potential of Silver nanoparticles synthesized using Pongamia pinnata leaf extract in male wistar rats for the development of a male contraceptive agent

Biomedical and Therapeutics Letters
Plant-mediated silver nanoparticles (AgNPs) possess a variety of biological properties, such as antibacterial, anti-inflammatory, and antifertility properties. The plant we used in this study is Pongamia pinnata, which have multiple medicinal values.
Prity Yadav, Neha Bharti, Sandeep Kumar Choudhary, Rajeev Kumar Dhaked, Pratap Chand Mali   +4 more
openaire   +1 more source

Dual Artery Compression for Patent Hemostasis and Prevention of Radial Artery Occlusion: The Quebec Terry2 Registry

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background Radial artery occlusion (RAO) is a common complication following transradial artery access (TRA). Patent hemostasis is recommended to reduce RAO. Prophylactic ulnar artery compression is a technique to increase the rate of patent hemostasis.
Tomas A. Cieza, Francis Bonnenfant, Jimmy MacHaalany, Paola Ulacia‐Flores, Safia Ouarrak, Andres Ruhl, Erika Pomerleau, Joany Lapierre, Olivier F. Bertrand   +8 more
wiley   +1 more source

Engineering Lipid Nanoparticles for Precision RNA Delivery: Design Principles, Targeting Strategies, and Clinical Prospects

Cancer Nexus, EarlyView.
ABSTRACT Lipid nanoparticles (LNPs) represent the most clinically advanced platform for RNA delivery and have enabled major breakthroughs in vaccines and gene therapies. However, their broader application is still limited by inefficient extrahepatic delivery, immunogenicity, and insufficient control over tissue‐ and cell‐specific targeting. This review
Yu Han, Ying Wang, Xintao Gao, Yan Lei, Yantao Li, Zhiyong Tang   +5 more
wiley   +1 more source

Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs

Clinical Pharmacology &Therapeutics, EarlyView.
Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri, Islam R. Younis, Shadia I. Jalal, Theodore F. Logan, Rohan Maniar, Steven M. Bray, Sara K. Quinney, Zeruesenay Desta, Todd C. Skaar, James E. Tisdale, Tyler Shugg   +10 more
wiley   +1 more source

Silodosin-induced anejaculation: a promising agent for male oral contraception

Background: The objective of this study was to investigate the feasibility of utilizing silodosin as a non-hormonal, reversible, oral contraceptive for men, alongside elucidating its mechanism of action pertaining to ejaculatory dysfunction. Methods: This is a non-controlled open-label study. Thirty-five sexually active male volunteers, aged between 50
Sönmez, Berat, Uzun, Hakkı, Yiğit, Merve Hüner, Akça, Görkem, Dil, Eyüp, Orman, Erdem, Kaçan, Yakup   +6 more
openaire   +1 more source