Results 161 to 170 of about 23,388 (244)

Physiologically based pharmacokinetic modeling and simulation of topiramate in populations with renal and hepatic impairment and considerations for drug–drug interactions

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 510-522, March 2025.
Abstract Topiramate (TPM) is a broad‐spectrum antiepileptic drug (AED) commonly prescribed for approved and off‐label uses. Routine monitoring is suggested for clinical usage of TPM in special population due to its broad side effect profile. Therefore, it is crucial to further explore its pharmacokinetic characteristics.
Shuqing Chen, Chaozhuang Shen, Yuchen Tian, Yuhe Peng, Jing Hu, Haitang Xie, Ping Yin   +6 more
wiley   +1 more source

Understanding Problematic Bleeding When Using Contraception: Guidance for Clinicians. [PDF]

Open Access J Contracept
Barretta M, Grandi G.
europepmc   +1 more source

Evaluation of Potential Hormonal Activities of Ashwagandha (Withania somnifera)

Phytotherapy Research, EarlyView.
ABSTRACT Ashwagandha is a widely used herb in traditional medicine systems, particularly Ayurveda. Despite its extensive tradition, growing concerns regarding its potential endocrinological effects have prompted scientific scrutiny. This review systematically evaluates the current preclinical, clinical, and case study evidence concerning AS's effects ...
Günter Vollmer, Thomas Brendler
wiley   +1 more source

Cardiac disease in systemic sclerosis: Integrating pathobiology with clinical management

Rheumatology &Autoimmunity, EarlyView.
Abstract Systemic sclerosis (SSc) is a complex autoimmune disorder in which cardiovascular involvement remains a major determinant of morbidity and mortality. Cardiac injury in SSc results from the interplay of microvascular dysfunction, immune‐mediated inflammation, and progressive interstitial and replacement fibrosis, leading to myocardial disease ...
Henry Sutanto, Betty Rachma, Yuliasih
wiley   +1 more source

Pathophysiological Consequences Associated with Hormonal Contraceptives Use in Sub-Saharan Africa: A Scoping Review. [PDF]

Open Access J Contracept
Kampire MG, Hakizimana JC, Mucumbitsi J, Alagbonsi AI.   +3 more
europepmc   +1 more source

Clinical characteristics of immediate allergic adverse reactions to intravenous amoxicillin‒clavulanic acid in conscious dogs

Veterinary Record, EarlyView.
Abstract Background Amoxicillin‒clavulanic acid (AMC) is one of the most frequently used antibiotics in small animal practice, and reports on adverse reactions are scarce. The aim of this study was to describe the clinical characteristics of immediate allergic adverse reactions to intravenous (IV) AMC in conscious dogs. Methods The medical records of a
Leonel Frutuoso, Anna Threlfall
wiley   +1 more source

The use of hormonal contraceptives in high performance Brazilian female swimmers: a cross-sectional study. [PDF]

Rev Bras Ginecol Obstet
Carvalho AC, Gaio N, Müller PC, Benincá SC.   +3 more
europepmc   +1 more source

Impact of an ERAS‐Based Surgical Care Bundle Implementation for Preventing Anastomotic Leakage in Minimally Invasive Low Anterior Resection for Rectal Cancer: A Retrospective Cohort Study

World Journal of Surgery, EarlyView.
Anastomotic leakage (AL) remains a severe complication after low anterior resection (LAR) for rectal cancer, despite advances in minimally invasive (MI) techniques. This study aimed to evaluate the impact of a surgery‐focused care bundle, implemented on an enhanced recovery after surgery (ERAS)‐based perioperative protocol, on preventing AL and ...
Koji Tamura, Takaaki Fujimoto, Jinghui Zhang, Kinuko Nagayoshi, Yusuke Mizuuchi, Kohei Horioka, Naoki Ikenaga, Kohei Nakata, Kenoki Ohuchida, Masafumi Nakamura   +9 more
wiley   +1 more source

Evidence Suggests Prophylactic Antibiotics May Be Unnecessary in Anorectal Surgery—A Systematic Review and Meta‐Analysis

World Journal of Surgery, EarlyView.
Current evidence does not support the routine use of prophylactic antibiotics in uncomplicated anorectal procedures. However, the certainty of evidence is limited by small sample sizes, methodological heterogeneity, and limited number of available studies. Large‐scale randomized trials are required to strengthen this evidence base.
James Jin, Velia Men, Maggie Wang, Andrew Hill   +3 more
wiley   +1 more source

Effects of combined oral contraceptives and metformin on paraoxonase 1 lactonase activity and status in patients with polycystic ovary syndrome and insulin resistance. [PDF]

Front Endocrinol (Lausanne)
Liang J, Wang Q, Liu D, Wu L, Qiao X, Wang R, Zhong Y, Bo W, Lai H, Fan P, Huang W.   +10 more
europepmc   +1 more source