Results 61 to 70 of about 5,539 (231)
Kanzo, 1986 経口避妊薬の肝発癌性,並びに発生した肝腫瘍のホルモン依存性を検索する目的で以下の研究を行った.生後4週齢のWistar/JCL雌ラットに硬性胃ゾンデを用いて毎日強制的に1年間にわたり下記の薬剤を1日1回投与した.I群:ethinylestradiol 0.075mg+norethindrone acetate 6mg in 0.5ml olive oil, II群:I群の倍量.III群・IV群:I群及びII群の対照としてolive oilのみをそれぞれ0.5mlまたは1.0ml.薬剤投与終了の時点で,対照としたIII群及びIV群では全く腫瘍の発生を認めなかったが,I群:38匹中6匹(15.8%),II群:27匹中6匹(22.2%)に高分化型肝細胞癌の発生を認めた.ついでホルモンの投与を中止したところ,
openaire +2 more sources
Future Postharvest and Food, EarlyView.By lowering oxidative stress and lens protein aggregation, nutraceuticals enriched with antioxidants may reduce the development of senile cataracts, demonstrating their potential as supplemental, non‐pharmacological cataract preventive methods. ABSTRACT This review explores the emerging evidence to accommodate the developing requirement of non ...
Moubani Dutta +2 more
wiley +1 more source
Food Safety and Health, EarlyView.Whey protein‐based microencapsulation for omega‐3 PUFA delivery in food systems. Objective: Enhance oxidative stability & bioavailability of omega‐3 PUFAs using whey protein as an encapsulating agent. Current methods: Spray drying & coacervation—effective but limited by heat sensitivity and encapsulation efficiency. Emerging technologies: Electrospray &
Jihan M. Kassem +9 more
wiley +1 more source
Harnessing Free Radical Scavenging Potential of Caffeic Acid as a Nutraceutical—A Review
Food Safety and Health, EarlyView.Caffeic acid has emerged as a promising bioactive molecule with multiple pharmacological properties, including antioxidant, antimicrobial, anti‐inflammatory, organ protective properties and metal‐chelating ability. This review emphasizes the dietary sources, structural characteristic, molecular mechanism underlying health promoting effects of caffeic ...
Pavitra Behra +2 more
wiley +1 more source
Nomogram for Predicting Osteoradionecrosis After Fibula Free Flap for Mandibular Reconstruction
Head &Neck, EarlyView.ABSTRACT Background Osteoradionecrosis (ORN) is a severe complication following radiotherapy (RT), particularly after mandibular reconstruction with a fibula free flap. Risk prediction remains challenging due to limited data. Methods We conducted a multicenter retrospective study including 294 patients who underwent fibula free flap reconstruction and ...
Andrea Costantino +15 more
wiley +1 more source
Combined oral contraceptives with estetrol: Reduced risk of thrombosis and other benefits. A review
ГинекологияDemographic trends indicate a decrease in the number of children per woman, a change in reproductive patterns and a late age of motherhood. These factors increase the importance of effective contraception.
N. M. Podzolkova +3 more
doaj +1 more source
Therapeutic role of nifedipine in threatened preterm labor: Current evidence and future perspectives
International Journal of Gynecology &Obstetrics, EarlyView.Abstract Preterm birth occurs in approximately 10% of all pregnancies, and is not only the leading cause of neonatal mortality but also a major contributor to short‐ and long‐term morbidities due to immaturity. Preterm birth has also been linked to an increased risk of maternal cardiovascular and cerebrovascular diseases, making it a critical concern ...
Hikaru Imatake +4 more
wiley +1 more source
Tracing the evolution of root coverage: Clinical milestones leading to a minimally invasive era
Journal of Periodontology, EarlyView.Abstract Over the past several decades, periodontal plastic surgery has undergone a remarkable transformation, particularly in the field of root coverage procedures. This review traces the historical evolution of surgical techniques, from the early use of pedicle flaps and free gingival grafts (FGGs) to the development of bilaminar approaches ...
Lorenzo Tavelli +6 more
wiley +1 more source
Environment InternationalCombined oral contraceptives, comprising of both an oestrogen and a progestin component, are released in aquatic environments and potentially pose a risk to aquatic wildlife by their capacity to disrupt physiological mechanisms.In this study, the ...
Sébastien Baekelandt +9 more
doaj +1 more source
Journal of Periodontology, EarlyView.Abstract Background Fibroblast growth factor‐2 (FGF‐2) is a novel agent utilized in periodontal regeneration therapy. However, its clinical efficacy compared with autologous bone graft (ABG), a long‐established treatment, remains unclear. This study aimed to compare the clinical outcomes of FGF‐2 and ABG and to assess the impact of patient background ...
Toshiki Matsumoto +11 more
wiley +1 more source