Results 41 to 50 of about 8,636 (179)

The Effect of Overexpressed DdRabS on Development, Cell Death, Vesicular Trafficking, and the Secretion of Lysosomal Glycosidase Enzymes

Biology, 2018
Rab GTPases are essential regulators of many cellular processes and play an important role in downstream signaling vital to proper cell function. We sought to elucidate the role of novel D. discoideum GTPase RabS.
Azure Yarbrough, Katherine Maringer, Entsar J. Saheb, Sanaa Jawed, John Bush   +4 more
doaj   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Canagliflozin protects cardiovascular function in type 2 diabetic coronary artery disease by regulating natriuretic peptide B

Journal of Diabetes Investigation, EarlyView.
Canagliflozin regulated the cyclic guanosine monophosphate (cGMP)‐protein kinase 1‐α signaling pathway through the natriuretic peptide B gene, thereby improving cell viability, apoptosis, and reactive oxygen species levels, and ultimately protecting cardiac function in type 2 diabetic patients with coronary artery disease.
Jiarui Zhang, Lichenlu Huang, Yongqin Zheng, Ji Yang, Xiaopei Wu, Jundong He   +5 more
wiley   +1 more source

Subcellular localization of ammonium transporters in Dictyostelium discoideum

BMC Cell Biology, 2008
Background With the exception of vertebrates, most organisms have plasma membrane associated ammonium transporters which primarily serve to import a source of nitrogen for nutritional purposes.
Davis Carter T, Xiong Yanhua, Kirsten Janet H, Singleton Charles K   +3 more
doaj   +1 more source

The Contractile Vacuole and Related Structures in Tetrahymena pyriformis* [PDF]

The Journal of Protozoology, 1964
SYNOPSIS. The nephridial system of T. pyriformis consists of a contractile vacuole with its two pores and an elaborate network of tubules. Both the vacuole and its tubules constitute a continuous system of single membranes of approximately 70 Å in thickness. Tubular fibrils of about 250 Å extend from the pore wall to the vacuole membrane and appear to
Elliott, Alfred M., Bak, Il Jin
openaire   +4 more sources

High‐throughput screening identifies bazedoxifene as a potential therapeutic for dysferlin‐deficient limb girdle muscular dystrophy

British Journal of Pharmacology, Volume 182, Issue 13, Page 2930-2949, July 2025.
Abstract Background and Purpose Limb‐girdle muscular dystrophy R2 (LGMD R2) is a rare genetic disorder characterised by progressive weakness and wasting of proximal muscles. LGMD R2 is caused by the loss of function of dysferlin, a transmembrane protein crucial for plasma membrane repair in skeletal muscles.
Celine Bruge, Nathalie Bourg, Emilie Pellier, Johana Tournois, Jerome Polentes, Manon Benabides, Noella Grossi, Anne Bigot, Anthony Brureau, Isabelle Richard, Xavier Nissan   +10 more
wiley   +1 more source

Mitochondria‐Homing Drug Mitochonic Acid 5 Improves Barth Syndrome Myopathy in a Human‐Induced Pluripotent Stem Cell Model and Barth Syndrome Drosophila Model

The FASEB Journal, Volume 39, Issue 12, 30 June 2025.
Barth syndrome (BTHS) is a rare disease caused by mutations in the tafazzin gene that affects the heart and muscles, but till date, no clinically effective drugs. Using Barth syndrome myopathy in human‐ iPS‐derived disease cells and Drosophila melanogaster model, a new mitochondria‐homing drug MA‐5, improves BTHS dysfunction and may serve as a new ...
Yoshiyasu Tongu, Tomoko Kasahara, Tetsuro Matsuhashi, Yoshitsugu Oikawa, Ryota Akimoto, Yuhan Luo, Sayaka Sekine, Momoka Suzuki, Hitomi Kashiwagi, Shinichiro Kanno, Yoshikazu Tanaka, Kyohei Sato, Yusuke Okubo, Akihiko Muto, Hidetaka Tokuno, Chitose Suzuki, Chiharu Kawabe, Takamasa Ishikawa, Shun Watanabe, Koichi Kikuchi, Shun Itai, Takeya Sato, Takehiro Suzuki, Kazuhiro Igarashi, Shinji Fukuda, Tomoyoshi Soga, Kei Murayama, Erina Kuranaga, Takafumi Toyohara, Takaaki Abe   +29 more
wiley   +1 more source

Abiotic Stress‐Induced Chloroplast and Cytosolic Ca2+ Dynamics in the Green Alga Chlamydomonas reinhardtii

Plant, Cell &Environment, Volume 48, Issue 6, Page 3939-3954, June 2025.
ABSTRACT Calcium (Ca2+)‐dependent signalling plays a well‐characterised role in the perception and response mechanisms to environmental stimuli in plant cells. In the context of a constantly changing environment, it is fundamental to understand how crop yield and microalgal biomass productivity are affected by external factors. Ca2+ signalling is known
Matteo Pivato, Alex Costa, Glen Wheeler, Matteo Ballottari   +3 more
wiley   +1 more source

Rapid osmocontractile response of motor cells of Mimosa pudica pulvini induced by short light signals

Photochemistry and Photobiology, Volume 101, Issue 3, Page 728-745, May/June 2025.
White light signals lasting less than 30 s induced rapid drop (1 s) of some Mimosa pudica leaves, resulting from osmocontraction of the pulvinar motor cells (A). An early signal detected after about 5 s is a change in motor cell membrane potential, depending on the wavelength applied (B).
Gabriel Roblin, Christelle Moyen, Pierrette Fleurat‐Lessard, Fabienne Dédaldéchamp   +3 more
wiley   +1 more source

TcCARP3 modulates compartmentalized cAMP signals involved in osmoregulation, infection of mammalian cells, and colonization of the triatomine vector in the human pathogen Trypanosoma cruzi

mBio
Trypanosoma cruzi is the causative agent of Chagas disease, a zoonotic infectious disease considered a leading cause of cardiomyopathy, disability, and premature death in the Americas.
Joshua Carlson, Milad Ahmed, Riley Hunter, Syeda Farjana Hoque, Joshua B. Benoit, Miguel A. Chiurillo, Noelia Lander   +6 more
doaj   +1 more source