Results 51 to 60 of about 8,636 (179)

Nramp1 and NrampB Contribute to Resistance against Francisella in Dictyostelium

Frontiers in Cellular and Infection Microbiology, 2017
The Francisella genus comprises highly pathogenic bacteria that can cause fatal disease in their vertebrate and invertebrate hosts including humans. In general, Francisella growth depends on iron availability, hence, iron homeostasis must be tightly ...
Yannick Brenz, Denise Ohnezeit, Hanne C. Winther-Larsen, Monica Hagedorn   +3 more
doaj   +1 more source

Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine‐Induced Cachexia

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 2, April 2025.
Abstract Background Cachexia is a severe form of muscle wasting disorder particularly observed in patients with advanced cancer. The absence of effective strategies to ameliorate cachexia indicates our poor understanding of the mechanisms of cachexia. By employing system‐wide approaches, we investigated molecular mechanisms underlying cancer secreted ...
Luis Vincens Gand, Chiara Lanzuolo, Mugeng Li, Valentina Rosti, Natalie Weber, Dongchao Lu, Christian Bär, Thomas Thum, Andreas Pich, Theresia Kraft, Mamta Amrute‐Nayak, Arnab Nayak   +11 more
wiley   +1 more source

Iron metabolism and resistance to infection by invasive bacteria in the social amoeba Dictyostelium discoideum

Frontiers in Cellular and Infection Microbiology, 2013
Dictyostelium cells are forest soil amoebae, which feed on bacteria and proliferate as solitary cells until bacteria are consumed. Starvation triggers a change in life style, forcing cells to gather into aggregates to form multicellular organisms ...
Salvatore eBozzaro, Simona eBuracco, Barbara ePeracino   +2 more
doaj   +1 more source

Hepatic Steatosis Aggravates Vascular Calcification via Extracellular Vesicle‐Mediated Osteochondrogenic Switch of Vascular Smooth Muscle Cells

Advanced Science, Volume 12, Issue 5, February 3, 2025.
Steatotic hepatocytes‐derived extracellular vesicles (SHep‐EVs) in the liver of mice with metabolic dysfunction‐associated fatty liver disease (MAFLD) can be transferred to vascular smooth muscle cells (VSMCs), exacerbating atherosclerosis and calcification by delivering Lgals3bp.
Zhao‐Lin Zeng, Zhi‐Bo Zhao, Qing Yuan, Shi‐Qi Yang, Zhen‐Xing Wang, Zuo Wang, Shi‐Yu Zeng, An‐Qi Li, Qian Chen, Guo‐Qiang Zhu, Xin‐Hua Xiao, Guang‐Hua Luo, Hai‐Yan Luo, Jiao‐Yang Li, Xu‐Yu Zu, Hui Xie, Jiang‐Hua Liu   +16 more
wiley   +1 more source

Loss of Cln3 function in the social amoeba Dictyostelium discoideum causes pleiotropic effects that are rescued by human CLN3.

PLoS ONE, 2014
The neuronal ceroid lipofuscinoses (NCL) are a group of inherited, severe neurodegenerative disorders also known as Batten disease. Juvenile NCL (JNCL) is caused by recessive loss-of-function mutations in CLN3, which encodes a transmembrane protein that ...
Robert J Huber, Michael A Myre, Susan L Cotman   +2 more
doaj   +1 more source

The behaviour of contractile vacuole complexes of cryptophycean flagellates [PDF]

British Phycological Journal, 1981
The behaviour of contractile vacuole complexes of representatives of the Cryptophycean genera Chilomonas, Cryptomonas, Cyathomonas and Rhodomonas is described using light and electron microscopy. The contractile vacuole occupies a fixed position in the cell, lying adjacent to the flagellar pocket/groove.
Klaus Hausmann, David J. Patterson
openaire   +2 more sources

Characterization of SARS‐CoV‐2 Entry Genes in Skeletal Muscle and Impacts of In Vitro Versus In Vivo Infection

Journal of Cachexia, Sarcopenia and Muscle, Volume 16, Issue 1, February 2025.
ABSTRACT Background COVID‐19 has been associated with both respiratory (diaphragm) and non‐respiratory (limb) muscle atrophy. It is unclear if SARS‐CoV‐2 infection of skeletal muscle plays a role in these changes. This study sought to: 1) determine if cells comprising skeletal muscle tissue, particularly myofibres, express the molecular components ...
Salyan Bhattarai, Eva Kaufmann, Feng Liang, Yumin Zheng, Ekaterina Gusev, Qutayba Hamid, Jun Ding, Maziar Divangahi, Basil J. Petrof   +8 more
wiley   +1 more source

Vascular endothelial cell injury: causes, molecular mechanisms, and treatments

MedComm, Volume 6, Issue 2, February 2025.
Endothelial cell injury is considered a critical initiating factor in the pathogenesis of various diseases, triggered by multiple factors such as disturbed shear stress and mechanical injury, environmental toxins, metabolic disorders, bacterial/viral infections, and dyslipidemia.
Tian Xia, Jiachi Yu, Meng Du, Ximeng Chen, Chengbin Wang, Ruibing Li   +5 more
wiley   +1 more source

Standardisation of Dog Sperm Morphology Classification

Reproduction in Domestic Animals, Volume 60, Issue 2, February 2025.
ABSTRACT Sperm morphology is an important component of dog fertility analysis. Visual examination is the gold standard technique for evaluation, but large variations within and across evaluators have been documented. Databases of sperm morphology images are valuable practical aids for training and performance testing and can improve sperm ...
Leonardo F. C. Brito, Marco C. da Silva, Kara A. Kolster   +2 more
wiley   +1 more source

The effect of ionizing radiation on testicular interstitial stromal cells

Reproductive Medicine and Biology, Volume 24, Issue 1, January/December 2025.
The interstitial stromal cells play an important supportive role in male fertility, but radiation‐induced damage to these cells is still poorly understood. We aimed to investigate the impact of a high (1 Gy) and very high (8 Gy) single pelvic radiotherapy on pubertal testicular histology and factors such as CSF‐1R, CD105, FGF2, and GNDF to study the ...
Esraa Tamam, Chen Yan, Reiko Sekiya, Tao‐Sheng Li   +3 more
wiley   +1 more source