Results 91 to 100 of about 244,667 (356)

Probing Early Particle‐Cell Membrane Interactions via Single‐Cell and Single‐Particle Interaction Analysis

Advanced Functional Materials, EarlyView.
The pre‐internalization phase of endocytosis remains poorly characterized at single‐cell levels. Single‐cell pre‐internalization mechanics are investigated using advanced robotic techniques. Cancer cells exhibit biphasic adhesion – rapid initial binding followed by reinforcement – while fibroblasts show gradual engagement.
Houari Bettahar, Christos Tapeinos, Oğulcan Işıtman, Carmine D'Amico, Alexandra Correia, Hélder A. Santos, Quan Zhou   +6 more
wiley   +1 more source

Polarized cortical tension drives zebrafish epiboly movements [PDF]

, 2016
The principles underlying the biomechanics of morphogenesis are largely unknown. Epiboly is an essential embryonic event in which three tissues coordinate to direct the expansion of the blastoderm.
Amayra Hernández‐Vega, Concha ML, Daniel Navajas, Enrique Martín‐Blanco, Ignacio Pagonabarraga, Julien Colombelli, María Marsal, Philippe‐Alexandre Pouille, Solnica‐Krezel L, Sébastien Tosi, Tomás Luque, Warga RM, Weliky M, Westerfield M   +13 more
core   +2 more sources

Cell‐Delivering Injectable Hydrogels with Tunable Microporous Structures Improve Therapeutic Efficacy for Volumetric Muscle Loss

Advanced Functional Materials, EarlyView.
The study presents an injectable hydrogel with tunable microporosity to improve mesenchymal stem cell delivery for volumetric muscle loss treatment. Mesenchymal stem cells encapsulated in porous hydrogels significantly promote the spreading, proliferation, and cytokine secretion of mesenchymal stem cells.
Hana Yasue, Tetsushi Taguchi, Taka‐Aki Asoh, Akihiro Nishiguchi   +3 more
wiley   +1 more source

Engineering Topographical Cues to Enhance Neural Regeneration in Spinal Cord Injury: Overcoming Challenges and Advancing Therapies

Advanced Functional Materials, EarlyView.
Spinal cord injury (SCI) poses significant challenges for regeneration due to a series of secondary injury mechanisms. How to use biomaterial approach to target the failed regeneration after SCI remains a critical challenge. This review systematically evaluates current strategies to optimize biomaterial topographies for neurite outgrowth, axonal ...
Wei Xu, Fenghui Wang, Joshua Stein, Siqiao Wang, Pengfei Jiang, Letao Yang, Liming Cheng, Ki‐Bum Lee   +7 more
wiley   +1 more source

Substrate Stress Relaxation Regulates Cell‐Mediated Assembly of Extracellular Matrix

Advanced Functional Materials, EarlyView.
Silicone‐based viscoelastic substrates with tunable stress relaxation reveal how matrix mechanics regulates cellular mechanosensing and cell‐mediated matrix remodelling in the stiff regime. High stress relaxation promotes assembly of fibronectin fibril‐like structures, increased nuclear localization of YAP and formation of β1 integrin‐enriched ...
Jonah L. Voigt, Jens Timmer, Elisabetta Ada Cavalcanti‐Adam   +2 more
wiley   +1 more source

CSE-Induced ER-Mitochondria Crosstalk Promotes Oxidative Stress and Impairs Bronchial Contractile Response

Antioxidants
Chronic obstructive pulmonary disease (COPD), whose main risk factor is cigarette smoking, is among the most prevalent diseases worldwide. Previous studies have shown that cigarette smoke extract (CSE) can directly affect pulmonary artery function ...
Jorge Rodríguez-Pérez, Rosa Andreu-Martínez, Leila Pérez-Sánchez, Ana Hernández-García, Cecilia Muñoz-Calleja, Ángel Cogolludo, María J. Calzada   +6 more
doaj   +1 more source

Guanidine Affects Differentially the Twitch Response of Diaphragm, Extensor Digitorum Longus and Soleus Nerve-Muscle Preparations of Mice

Molecules, 2012
Guanidine has been used with some success to treat myasthenia gravis and myasthenic syndrome because it increases acetylcholine release at nerve terminals through K⁺, Na⁺ and Ca²⁺ ...
Maria Alice da Cruz Höfling, Rosana Ferrari, Léa Rodrigues-Simioni   +2 more
doaj   +1 more source

Neural regulation of cardiovascular response to exercise: role of central command and peripheral afferents [PDF]

, 2014
During dynamic exercise, mechanisms controlling the cardiovascular apparatus operate to provide adequate oxygen to fulfill metabolic demand of exercising muscles and to guarantee metabolic end-products washout.
Crisafulli, A, Marongiu, E, Nobrega, ACL, O'Leary, D, Piepoli, MF, Silva, BM   +5 more
core   +4 more sources

Engineering Highly Cellularized Living Materials via Mechanical Agitation

Advanced Functional Materials, EarlyView.
A mechanical agitation strategy is developed to engineer highly cellularized living materials, achieving cell densities of up to 1 billion cells per milliliter. By precisely tuning properties such as stiffness and toughness in blood clots, the approach is validated in both in vitro and in vivo studies.
Aram Bahmani, Shiyu Liu, Evan Johnston, Weiyi Wan, Xiaoyi Lan, Tianqin Ning, Alexander Nottegar, Ran Huo, Shuaibing Jiang, Jianyu Li   +9 more
wiley   +1 more source

Cardioprotective effect of peptide and non-peptide opioid receptor agonists in cardiac reperfusion: potential clinical application of experimental data

Сибирский научный медицинский журнал
Mortality in patients with acute myocardial infarction is 5–8 % and has not decreased in recent years. One of the causes of death is reperfusion cardiac injury. It is quite obvious that there is an urgent need to develop drugs that can effectively reduce
A. V. Mukhomedzyanov, L. N. Maslov, S. V. Popov, A. S. Slidnevskaya, A. Kan, N. V. Naryzhnaya   +5 more
doaj   +1 more source