Results 91 to 100 of about 254,999 (359)

Time-of-day effects on muscle mitochondria following short-term ablation of satellite cells

Frontiers in Physiology
IntroductionEndurance exercise capacity fluctuates by time-of-day due, in part, to molecular clock effects on muscle physiology. As endurance-based exercise relies predominantly on mitochondria for the conversion of cellular energy, fluctuations observed
Ryan E. Kahn, Ryan E. Kahn, Fawzan Dinnunhan, Guadalupe Meza, Richard L. Lieber, Richard L. Lieber, Richard L. Lieber, Orly Lacham-Kaplan, John A. Hawley, John A. Hawley, Sudarshan Dayanidhi, Sudarshan Dayanidhi   +11 more
doaj   +1 more source

Long-Term Regulation of Excitation–Contraction Coupling and Oxidative Stress in Cardiac Myocytes by Pirfenidone

Frontiers in Physiology, 2018
Pirfenidone (PFD) is used to treat human pulmonary fibrosis. Its administration to animals with distinct forms of cardiovascular disease results in striking improvement in cardiac performance.
Adrián Monsalvo-Villegas, Diana Stephanie Osornio-Garduño, Guillermo Avila   +2 more
doaj   +1 more source

Requirements for contractility in disordered cytoskeletal bundles

, 2012
Actomyosin contractility is essential for biological force generation, and is well understood in highly organized structures such as striated muscle. Additionally, actomyosin bundles devoid of this organization are known to contract both in vivo and in ...
Aaron R Dinner, Alberts B, Heath J P, Kruse K, Lenz M Thoresen T Gardel M L Dinner A R, Liverpool T B, Margaret L Gardel, Martin Lenz, Szent-Györgyi A   +8 more
core   +1 more source

Bioprinting Organs—Science or Fiction?—A Review From Students to Students

Advanced Healthcare Materials, EarlyView.
Bioprinting artificial organs has the potential to revolutionize the medical field. This is a comprehensive review of the bioprinting workflow delving into the latest advancements in bioinks, materials and bioprinting techniques, exploring the critical stages of tissue maturation and functionality.
Nicoletta Murenu, Camilla Mussoni, Mateo S. Andrade Mier, Paula Buettner, Nathaly Chicaiza‐Cabezas, Yi‐Yu Robin Dai, Jessica Faber, Maren Fiedler, Zan Lamberger, Xuen Jen Ng, Vanessa Moessler, Anna Rederer, Jonas Roeder, Sabrina Stecher, Katinka Theis, Jeanette Weigelt, Silvia Budday, Gregor Lang, Natascha Schaefer   +18 more
wiley   +1 more source

Cardioprotective effect of peptide and non-peptide opioid receptor agonists in cardiac reperfusion: potential clinical application of experimental data

Сибирский научный медицинский журнал
Mortality in patients with acute myocardial infarction is 5–8 % and has not decreased in recent years. One of the causes of death is reperfusion cardiac injury. It is quite obvious that there is an urgent need to develop drugs that can effectively reduce
A. V. Mukhomedzyanov, L. N. Maslov, S. V. Popov, A. S. Slidnevskaya, A. Kan, N. V. Naryzhnaya   +5 more
doaj   +1 more source

Precise Control of Drug Release in Machine Learning‐Designed Antibody‐Eluting Implants for Postoperative Scarring Inhibition in Glaucoma

Advanced Healthcare Materials, EarlyView.
We developed a micro‐sized, biocompatible implant for postoperative sustained delivery of anti‐fibrotic antibodies in glaucoma surgery. Machine learning‐guided optimization of polymer composition, implant geometry, and porosity enabled precise control of drug release.
Mengqi Qin, Wenbing Jiang, Kai Xin Thong, Zeynep Ulker, Brihitejas Patel, Cynthia Yu‐Wai‐Man   +5 more
wiley   +1 more source

Changes in Biventricular Cardiac Mechanics After Transcatheter Edge-to-Edge Repair for Severe Tricuspid Regurgitation

JACC: Advances
Background: Transcatheter edge-to-edge repair (TEER) is an established therapy for severe tricuspid regurgitation (TR). Invasive pressure-volume (PV) analysis is the gold standard for characterizing ventricular function and ventricular-vascular ...
Giulio M. Mondellini, MD, Antoon J.M. van den Enden, MD, Mark M.P. van den Dorpel, MD, Claire Ben Ren, MD, PhD, Christiaan L. Meuwese, MD, PhD, Isabella Kardys, MD, PhD, Rutger-Jan Nuis, MD, PhD, Maarten ter Horst, MD, PhD, Marcel L. Geleijnse, MD, PhD, Joost Daemen, MD, PhD, Daniel Burkhoff, MD, PhD, Nicolas M. Van Mieghem, MD, PhD   +11 more
doaj   +1 more source

Single‐Beat Estimation of Right Ventricular Contractility and Its Coupling to Pulmonary Arterial Load in Patients With Pulmonary Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundAn accurate assessment of intrinsic right ventricular (RV) contractility and its relation to pulmonary arterial load is essential for the management of pulmonary hypertension.
Ryo Inuzuka, Steven Hsu, Ryan J. Tedford, Hideaki Senzaki   +3 more
doaj   +1 more source

Immune cells and preterm labour:do invariant NKT cells hold the key? [PDF]

, 2015
We have developed our original made-to-measure (M2M) algorithm, PRIMAL, with the aim of modelling the Galactic disc from upcoming Gaia data. From a Milky Way like N-body disc galaxy simulation, we have created mock Gaia data using M0III stars as tracers,
Rinaldi, S F, Rossi, A G, Saunders, Philippa, Norman, J E   +3 more
core   +3 more sources

A Microphysiological Interface of Skeletal Myobundles and Inflamed Adipose Tissue for Recapitulating Muscle Dysfunction in an Obese Microenvironment

Advanced Healthcare Materials, EarlyView.
A human cell‐based microphysiological system integrates engineered muscle tissues with an inflamed adipose–macrophage niche to model obese microenvironment‐induced muscle dysfunction. Muscle contraction is quantified by pillar deflection coupled with computational stiffness estimation. Secretome and transcriptomic profiling reveal inflammation‐mediated
Seunggyu Kim, Tianxin Cao, Zhengpeng Wan, Jaesang Kim, Zhuxuan Li, Legairre A. Radden II, Rakesh Santhanam, Eunkyung Clare Ko, Tatsuya Osaki, Sarah Spitz, Hyunmin Moon, Maria Proestaki, Seokbeom Roh, Gyudo Lee, Jessie S. Jeon, Curtis R. Warren, Roger D. Kamm   +16 more
wiley   +1 more source