Results 91 to 100 of about 248,671 (308)

Time-of-day effects on muscle mitochondria following short-term ablation of satellite cells

Frontiers in Physiology
IntroductionEndurance exercise capacity fluctuates by time-of-day due, in part, to molecular clock effects on muscle physiology. As endurance-based exercise relies predominantly on mitochondria for the conversion of cellular energy, fluctuations observed
Ryan E. Kahn, Ryan E. Kahn, Fawzan Dinnunhan, Guadalupe Meza, Richard L. Lieber, Richard L. Lieber, Richard L. Lieber, Orly Lacham-Kaplan, John A. Hawley, John A. Hawley, Sudarshan Dayanidhi, Sudarshan Dayanidhi   +11 more
doaj   +1 more source

The intestinal expulsion of the roundworm Ascaris suum is associated with eosinophils, intra-epithelial T cells and decreased intestinal transit time [PDF]

, 2013
Ascaris lumbricoides remains the most common endoparasite in humans, yet there is still very little information available about the immunological principles of protection, especially those directed against larval stages.
A Fujiwara, A Roepstorff, A Zhao, A Zhao, Aaron R. Jex, BA Vallance, C Dold, C Moolenbeek, C Zhou, CD Criscione, CV Holland, D Leles, D Masure, Dries Masure, DW Crompton, F van Wijk, G Jungersen, GH Liu, HD Dawson, J Vandesompele, JF Urban Jr, Jimmy Saunders, Johnny Vlaminck, Jozef Vercruysse, KD Mccoy, Koen Chiers, L Eriksen, M Ashraf, M Morimoto, N Arizono, N Foster, N Miquel, NL Harris, P Kermanizadeh, P Nejsum, P O'Lorcain, PA Knight, Peter Geldhof, PI Uston, R Shamri, RM Anthony, RW Li, S Rozen, S Schmidt, Sarah Claerhoudt, Tao Wang, TB Stewart, TJ Anderson, Wim Van den Broeck   +48 more
core   +4 more sources

Nitric Oxide‐Releasing Catheters with Phenol‐Amine Catalytic Coatings for Improved Anti‐Inflammatory Performance

Advanced Healthcare Materials, EarlyView.
Tannic acid‐selenocystamine (TA‐SeCA) nanocoating enables stable, sustained catalytic nitric oxide (NO) release on catheter surfaces. This one‐step phenol‐amine coating improves catheter functionality by enhancing endogenous NO production, supporting vascular function, and reducing inflammation.
Qingqing Fan, Shu Geng, Tanveer A. Tabish, Kang Lin, Yiyi Yin, Siti Nur Asyura Adzlan, Federico Mazur, Rona Chandrawati   +7 more
wiley   +1 more source

Cardioprotective effect of peptide and non-peptide opioid receptor agonists in cardiac reperfusion: potential clinical application of experimental data

Сибирский научный медицинский журнал
Mortality in patients with acute myocardial infarction is 5–8 % and has not decreased in recent years. One of the causes of death is reperfusion cardiac injury. It is quite obvious that there is an urgent need to develop drugs that can effectively reduce
A. V. Mukhomedzyanov, L. N. Maslov, S. V. Popov, A. S. Slidnevskaya, A. Kan, N. V. Naryzhnaya   +5 more
doaj   +1 more source

Single‐Beat Estimation of Right Ventricular Contractility and Its Coupling to Pulmonary Arterial Load in Patients With Pulmonary Hypertension

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundAn accurate assessment of intrinsic right ventricular (RV) contractility and its relation to pulmonary arterial load is essential for the management of pulmonary hypertension.
Ryo Inuzuka, Steven Hsu, Ryan J. Tedford, Hideaki Senzaki   +3 more
doaj   +1 more source

Spontaneous formation of chaotic protrusions in a polymerizing active gel layer

, 2019
The actin cortex is a thin layer of actin filaments and myosin motors beneath the outer membrane of animal cells. It determines the cells' mechanical properties and forms important morphological structures.
Kruse, K., Levernier, N.
core   +2 more sources

Novel Drug‐Testing Platform for Vascular Injury‐induced Intimal Hyperplasia Using a Microphysiological System

Advanced Healthcare Materials, EarlyView.
This study develops a 3D vascular injury model using a microphysiological system that mimics key features of intimal hyperplasia. Antiproliferative drugs reduced VSMC proliferation but worsened endothelialdenudation. A combination of diphenyleneiodonium and quercetin effectively reduced proliferation and migration of VSMC and inflammation while ...
Ungsig Nam, HyeMi Kim, Jeong Ah Kim, Ki‐Hwan Nam, Kye‐Sung Lee, Hwan Hur, Jessie S. Jeon, Ji Yong Bae   +7 more
wiley   +1 more source

Cell Surface Thiol Engineering Mechanoregulates Myogenic Differentiation via the FAK–PI3K–AKT Axis

Advanced Healthcare Materials, EarlyView.
Schematic diagram illustrating how cell surface modification of skeletal muscle progenitor cells through TCEP treatment reveals enhanced cell adhesion, intracellular tension, and myogenesis at 19.66 kPa stiffness, leading to optimal cell fusion. In contrast, no significant changes are observed in the softer (10.61 kPa) or stiffer (49.4 kPa) matrices ...
Juyeon Kim, Sung Sik Hur, Jae Hong Park, Myung Jin Ban, Jin‐Young Kim, Joo Hyun Kim, Ji Hyae Choo, Hae‐Won Kim, Ju Hun Lee, Man Ryul Lee, Yongsung Hwang   +10 more
wiley   +1 more source

A Computational Journey Toward an Optimal Design for Metamaterial Epicardial Passive Sleeves

Advanced Healthcare Materials, EarlyView.
Passive epicardial sleeves are evaluated in 3D in‐silico heart models to reveal how sleeve geometry, stiffness, anisotropy, and metamaterial architecture influence cardiac mechanics after myocardial infarction. A continuum‐to‐auxetic design exploration shows that region‐specific mechanical engagement can reduce infarct bulging and modulate torsional ...
Vahid Naeini, Emilio A. Mendiola, Ahmad Rafsanjani, Fergal B. Coulter, Qian Xiang, Jianyi Zhang, Peter Vanderslice, Vahid Serpooshan, Reza Avazmohammadi   +8 more
wiley   +1 more source

The regulation of BK channel activity by pre- and post-translational modifications

Frontiers in Physiology, 2014
Large conductance, Ca2+-activated K+ (BK) channels represent an important pathway for the outward flux of K+ ions from the intracellular compartment in response to membrane depolarization, and/or an elevation in cytosolic free [Ca2+].
Barry D Kyle, Andrew P Braun
doaj   +1 more source