Results 101 to 110 of about 217,710 (307)

Effects of neuropeptide Y on electrical activity and myocardial contractility

Учёные записки Казанского университета: Серия Естественные науки, 2018
Neuropeptide Y (NPY) and agonist Leu(31)Pro(34)NPY were used to determine the type of NPY receptors involved in electrical activity and myocardial contraction.
A.A. Zverev, T.A. Anikina, N.G. Iskakov, A.V. Krulova, P.M. Masliukov, J.P. Timmermans, T.L. Zefirov   +6 more
doaj  

Phosphatidylinositol-3 kinase-Akt-mammalian target of rapamycin signaling pathway mediates contractility of human endometriotic stromal cells: A promising new target for the treatment of endometriosis-associated fibrosis

Gynecology and Minimally Invasive Therapy, 2014
Objective: To assess the involvement of phosphatidylinositol-3 kinase (PI3K)-Akt-mammalian target of rapamycin (mTOR) on the extracellular matrix contractility of endometriotic cells.
Wakana Abe, Kaei Nasu, Akitoshi Tsuno, Yukie Kawano, Hisashi Narahara   +4 more
doaj   +1 more source

Polarity patterns of stress fibers

, 2010
Stress fibers are contractile actomyosin bundles commonly observed in the cytoskeleton of metazoan cells. The spatial profile of the polarity of actin filaments inside contractile actomyosin bundles is either monotonic (graded) or periodic (alternating).
A. Verkhovsky, J. Prost, J.-F. Joanny, L. P. Cramer, N. Yoshinaga, P. Chaikin, P. Manneville, P. Marcq, P.-G. de Gennes, S. R. de Groot   +9 more
core   +3 more sources

Piezoelectric Surface Charge and Dynamic Stimulation Synergize to Promote Cardiac Myoblast Alignment and Maturation

Advanced Healthcare Materials, EarlyView.
Surface polarization of PVDF films combined with mechanical stimulation generates piezoelectric electrical cues that modulate cardiomyoblast behaviour. Non‐poled and poled PVDF substrates provide distinct electroactive microenvironments influencing cell adhesion, proliferation, and differentiation.
Rafaela M Meira, Sylvie Ribeiro, Senentxu Lanceros‐Mendez, Clarisse Ribeiro   +3 more
wiley   +1 more source

A Tri‐Culture Heart‐on‐a‐Chip Platform With iPSC‐Derived Cardiac Cells for Predictive Cardiotoxicity Testing

Advanced Healthcare Materials, EarlyView.
This study presents the first entirely isogenic heart‐on‐chip, unifying cardiomyocytes, fibroblasts, and endothelial cells from a single iPSC source. The platform reveals a critical biological insight: the endothelium actively shields cardiac tissue from drug‐induced toxicity, challenging the predictive accuracy of conventional, avascular models for ...
Karine Tadevosyan, Jose Yeste, Mar Alvarez, Denise Marrero, Laura Casado‐Medina, Yvonne Richaud‐Patin, Olalla García‐Iglesias, Jagoda Litowczenko, Alba Morillas Garcia, Anton Guimerà, Xavi Illa, Rosa Villa, Angel Raya   +12 more
wiley   +1 more source

In vitro study of spontaneous motility and cholinergic responses in the human Hirschsprung's disease colon

Frontiers in Pediatrics
BackgroundThe current standard treatment of Hirschsprung's disease (HD) involves complete resection of the aganglionic intestinal segment with routine rectal irrigation pre- and postoperatively.
Felix Schulze, Felix Schulze, Judith Lindert, Rüdiger Köhling, Rüdiger Köhling, Stefanie Märzheuser, Timo Kirschstein, Timo Kirschstein   +7 more
doaj   +1 more source

Spontaneous formation of chaotic protrusions in a polymerizing active gel layer

, 2019
The actin cortex is a thin layer of actin filaments and myosin motors beneath the outer membrane of animal cells. It determines the cells' mechanical properties and forms important morphological structures.
Kruse, K., Levernier, N.
core   +2 more sources

Common Signatures of Altered Gene Regulation and Invasiveness of Different Breast Cancer Cell Lines after Matrix Interface Crossing

Advanced Healthcare Materials, EarlyView.
Interface transmigration reprograms triple‐negative breast cancer cells, triggering a shared switch toward more aggressive and invasive phenotypes. Using a collagen I interface model, this study identifies shared transcriptional changes involving proliferation, chromatin remodeling, and DNA repair pathways.
Cornelia Clemens, Hannah Trampert, Nataliia Kotsiuba, Tilo Pompe   +3 more
wiley   +1 more source

Insights Into Transcriptional Dynamics of Tissue-Engineered Contractile Human Skeletal Muscle in Response to Electrical Pulse Stimulation

Tokyo Women's Medical University Journal
Background: The in vitro human skeletal muscle model is a valuable tool for studying muscle physiology and mechanisms underlying muscle diseases. Our previous work demonstrated that a tissue-engineering approach could produce contractile human muscle ...
Kanae Otsutomo, Hironobu Takahashi, Tatsuya Shimizu   +2 more
doaj   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source