Results 81 to 90 of about 122,620 (268)

In vitro study of spontaneous motility and cholinergic responses in the human Hirschsprung's disease colon

Frontiers in Pediatrics
BackgroundThe current standard treatment of Hirschsprung's disease (HD) involves complete resection of the aganglionic intestinal segment with routine rectal irrigation pre- and postoperatively.
Felix Schulze, Felix Schulze, Judith Lindert, Rüdiger Köhling, Rüdiger Köhling, Stefanie Märzheuser, Timo Kirschstein, Timo Kirschstein   +7 more
doaj   +1 more source

Heme‐NO Dilates Arteries via Mobilization of NO Moieties From an Intracellular NO Store Within Vascular Smooth Muscle Cells

Advanced Science, EarlyView.
Nitrosyl heme emerges as an extracellular nitrodilator that dilates arteries without crossing the cell membrane. Instead, heme‐NO mobilizes NO moieties from a preformed intracellular NO store within vascular smooth muscle, providing both functional and chemical evidence for the NANOS model, revealing a previously unrecognized mechanism of arterial ...
Taiming Liu, Meijuan Zhang, Lingchao Zhu, Haiyan Ke, Amancio de Souza, Qian Li, Daniel Castella, Nicolai Lehnert, Lubo Zhang, Arlin B. Blood   +9 more
wiley   +1 more source

TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension

eLife
The risk for developing primary open-angle glaucoma (POAG) correlates with the magnitude of ocular hypertension (OHT) and the concentration of transforming growth factor-β2 (TGFβ2) in the aqueous humor.
Christopher Nass Rudzitis, Monika Lakk, Ayushi Singh, Sarah N Redmon, Denisa Kirdajová, Yun-Ting Tseng, Michael L De Ieso, W Daniel Stamer, Samuel Herberg, David Krizaj   +9 more
doaj   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, EarlyView.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Corrigendum: Estimation of left ventricular end-systolic elastance from brachial pressure waveform via deep learning

Frontiers in Bioengineering and Biotechnology, 2023
Vasiliki Bikia, Marija Lazaroska, Deborah Scherrer Ma, Méline Zhao, Georgios Rovas, Stamatia Pagoulatou, Nikolaos Stergiopulos   +6 more
doaj   +1 more source

Time-of-day effects on muscle mitochondria following short-term ablation of satellite cells

Frontiers in Physiology
IntroductionEndurance exercise capacity fluctuates by time-of-day due, in part, to molecular clock effects on muscle physiology. As endurance-based exercise relies predominantly on mitochondria for the conversion of cellular energy, fluctuations observed
Ryan E. Kahn, Ryan E. Kahn, Fawzan Dinnunhan, Guadalupe Meza, Richard L. Lieber, Richard L. Lieber, Richard L. Lieber, Orly Lacham-Kaplan, John A. Hawley, John A. Hawley, Sudarshan Dayanidhi, Sudarshan Dayanidhi   +11 more
doaj   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source

Perfectly contractile graphs

Journal of Combinatorial Theory, Series B, 1990
Let f be a k-colouring of a graph G, \(1\leq i\neq j\leq k\), and H a connected component of the subgraph induced in G by \(f^{-1}(i)\cup f^{-1}(j)\). A new k-colouring g of G, which is said to be obtained from f by a k-switching, is defined by \(g(x)=f(x)\), if \(x\not\in H\); \(g(x)=i\), if \(x\in H\) and \(f(x)=j\); \(g(x)=j\), if \(x\in H\) and \(f(
openaire   +1 more source

Endoplasmic Reticulum Geometry Dictates Neuronal Bursting via Calcium Store Refill Rates and Exposes Selective Neuronal Vulnerability

Advanced Science, EarlyView.
The ER's continuous tubular network is maintained by ER‐shaping proteins whose mutation or dysregulation contributes to neurodegenerative diseases. Here, we show that ER morphology sets the speed of Ca2+ store replenishment between firing events. Disrupting ER continuity slows intra‐ER Ca2+ redistribution from extracellular refill (SOCE) sites, driving
Valentina Davi, Pierre Parutto, Yuyi Zhang, Tasuku Konno, Cecile Crapart, Raquel Pereira, John P. Franklin, Mosab Ali Awadelkareem, Daniel C Maddison, Michael J. Devine, Edgar R. Gomes, Joseph Chambers, Elena Koslover, Edward Avezov   +13 more
wiley   +1 more source